Limits of animal models in cancer chemotherapy.

Research output: Contribution to journalArticle

Abstract

In animals models used in cancer chemotherapy, there is a low variability in terms of sensitivity of cancer cells in vitro, plasma levels of anticancer drugs, and interhost immune responses. In contrast, human tumors (e.g., ovarian carcinoma) show much greater variability. It is suggested that greater attention should be given to the study of the variables which distinguish the clinical setting from the animal models.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Volume74
Publication statusPublished - 1980

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Animal Models
Drug Therapy
Neoplasms
Carcinoma
Pharmaceutical Preparations
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Limits of animal models in cancer chemotherapy.",
abstract = "In animals models used in cancer chemotherapy, there is a low variability in terms of sensitivity of cancer cells in vitro, plasma levels of anticancer drugs, and interhost immune responses. In contrast, human tumors (e.g., ovarian carcinoma) show much greater variability. It is suggested that greater attention should be given to the study of the variables which distinguish the clinical setting from the animal models.",
author = "S. Garattini",
year = "1980",
language = "English",
volume = "74",
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journal = "Recent Results in Cancer Research",
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