Lactose intolerance is diagnosed on the basis of both clinical and laboratory data. The most commonly used laboratory method is the OLT, even though it gives a rather high frequency of false positive results. OLT is an indirect method based on increase in glucose in plasma after a dose of lactose has been administered. Otherwise an incorrect diagnosis means that lactose and its derivatives are excluded from the diet, causing a loss of calories intake. Taking the idea that lactose intolerance shows a primitive or secondary lactase deficit, and that disaccharidase is localized in the brushborder, we studied the correlation between OLT, lactase activity in mucosa homogenate, histological pattern in 15 patients with malabsorption syndrome. The results we obtained confirm both the inadequacy of the OLT in diagnosing lactose intolerance and the good correlation between lactase activity and the histological pattern.
|Translated title of the contribution||Limits of lactose tolerance test in lactose intolerance|
|Number of pages||5|
|Publication status||Published - 1979|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health