Lineages, cell types and functional states: A genomic view

Renato Ostuni, Gioacchino Natoli

Research output: Contribution to journalArticlepeer-review

Abstract

Cellular differentiation progresses through an ordered cascade of events involving cell autonomous and micro-environment regulated expression or activation of transcription factors (TFs). Lineage-determining and stimulus-activated TFs collaborate in specifying the transcriptional programs of differentiating cells through the establishment of appropriate genomic repertoires of active or poised cis-regulatory elements, which can eventually be altered by environmental changes to generate transient or persistent functional states. Here, we rationalize available genomic and functional data into a mechanistic model whereby terminal differentiation proceeds first through the establishment of a regulatory landscape that is broadly shared among all cell types within a given lineage; and then through the selective activation of a more restricted set of regulatory elements that specify the unique transcriptional outputs of individual cell types. In this scheme, the interplay between cell-autonomous and microenvironment-regulated TFs is highly complex, with several documented variants.

Original languageEnglish
Pages (from-to)759-764
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume25
Issue number6
DOIs
Publication statusPublished - Dec 2013

ASJC Scopus subject areas

  • Cell Biology

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