Linear discriminant functions to improve the glaucoma probability score analysis to detect glaucomatous optic nerve heads: A multicenter study

Michele Iester, Francesco Oddone, Mirko Prato, Marco Centofanti, Paolo Fogagnolo, Luca Rossetti, Valeria Vaccarezza, Gianluca Manni, Antonio Ferreras

Research output: Contribution to journalArticle


Purpose: The purpose of the study was to create a linear discriminant function (LDF) formula by using the new Glaucoma Probability Score (GPS) global and sectorial optic nerve head parameters measured by Heidelberg Retinal Tomograph 3 to improve the GPS diagnostic capacity to discriminate between healthy and glaucomatous eyes. Patients and Methods: This is a multicenter cross-sectional study. To calculate the LDF formula, 137 normal individuals and 96 glaucomatous patients were selected. Another independent sample of 60 healthy and 69 glaucomatous eyes was used to evaluate the diagnostic accuracy of the LDF formulas. All patients underwent a full eye examination, standard achromatic perimetry by using Humphrey Field Analyzer, and imaging with Heidelberg Retinal Tomograph 3. Glaucoma was defined on the basis of SITA-24-2 visual field loss (pattern standard deviation P

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalJournal of Glaucoma
Issue number2
Publication statusPublished - Feb 2013



  • Confocal scanning laser
  • Disc area
  • Discriminant analysis formula
  • Glaucoma
  • Heidelberg Retina Tomography
  • Stage

ASJC Scopus subject areas

  • Ophthalmology

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