Linear polymers of β and γ cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin

Valentina Oliveri, Francesco Bellia, Maurizio Viale, Irena Maric, Graziella Vecchio

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclodextrins have been used to encapsulate drugs improving their stability and efficiently regulating their release. Polymeric nanoparticles containing cyclodextrins are currently undergoing clinical trials as nanotherapeutics. In this context, we have synthesized new linear polymers based on polyglutamic acid with pendant β- or γ-cyclodextrins, using a high yield reaction route. The new polymers with an average number of about 17 cyclodextrin cavities were characterized (NMR, MALDI-MS, DLS) and tested as carriers of doxorubicin in human tumor cells. They can include doxorubicin, and the inclusion complexes show antiproliferative activity in human tumor cells.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalCarbohydrate Polymers
Volume177
DOIs
Publication statusPublished - Dec 1 2017

Keywords

  • Cancer
  • Carbohydrates
  • Cyclodextrins
  • Drug
  • Nanoparticles
  • Polymers

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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