Abstract
We report an episode of severe bradycardia that occurred in a 49-year-old woman with fever and malignant jaundice during antibiotic therapy with linezolid, a new oxazolidinone with activity against Gram-positive cocci. In our case, the strict temporal dependence between bradycardia and linezolid therapy seems to provide strong evidence for a causal relationship. To our knowledge, this is the first report of linezolid-induced bradycardia. This adverse event confirms that the new antibiotic linezolid should be administered with caution in patient with jaundice and hepatic insufficiency.
Original language | English |
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Pages (from-to) | 412-413 |
Number of pages | 2 |
Journal | International Journal of Antimicrobial Agents |
Volume | 23 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2004 |
Keywords
- Bradycardia
- Linezolid
- Side effect
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Microbiology
- Parasitology
- Virology
- Immunology and Allergy
- Infectious Diseases