Linezolid-induced bradycardia: A case report

Alfredo Tartarone, Giuseppina Gallucci, Giovanni Iodice, Giampiero Romano, Mariarosa Coccaro, Maria Luigia Vigliotti, Giuseppe Mele, Rosella Matera, Nicola Di Renzo

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We report an episode of severe bradycardia that occurred in a 49-year-old woman with fever and malignant jaundice during antibiotic therapy with linezolid, a new oxazolidinone with activity against Gram-positive cocci. In our case, the strict temporal dependence between bradycardia and linezolid therapy seems to provide strong evidence for a causal relationship. To our knowledge, this is the first report of linezolid-induced bradycardia. This adverse event confirms that the new antibiotic linezolid should be administered with caution in patient with jaundice and hepatic insufficiency.

Original languageEnglish
Pages (from-to)412-413
Number of pages2
JournalInternational Journal of Antimicrobial Agents
Issue number4
Publication statusPublished - Apr 2004


  • Bradycardia
  • Linezolid
  • Side effect

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases


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