Linezolid-induced bradycardia: A case report

Alfredo Tartarone; Giuseppina Gallucci; Giovanni Iodice; Giampiero Romano; Mariarosa Coccaro; Maria Luigia Vigliotti; Giuseppe Mele; Rosella Matera; Nicola Di Renzo

doi:10.1016/j.ijantimicag.2003.10.001

Linezolid-induced bradycardia: A case report

Alfredo Tartarone, Giuseppina Gallucci, Giovanni Iodice, Giampiero Romano, Mariarosa Coccaro, Maria Luigia Vigliotti, Giuseppe Mele, Rosella Matera, Nicola Di Renzo

IRCCS Centro di Riferimento Oncologico della Basilicata (CROB)

Research output: Contribution to journal › Article › peer-review

Abstract

We report an episode of severe bradycardia that occurred in a 49-year-old woman with fever and malignant jaundice during antibiotic therapy with linezolid, a new oxazolidinone with activity against Gram-positive cocci. In our case, the strict temporal dependence between bradycardia and linezolid therapy seems to provide strong evidence for a causal relationship. To our knowledge, this is the first report of linezolid-induced bradycardia. This adverse event confirms that the new antibiotic linezolid should be administered with caution in patient with jaundice and hepatic insufficiency.

Original language	English
Pages (from-to)	412-413
Number of pages	2
Journal	International Journal of Antimicrobial Agents
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.ijantimicag.2003.10.001
Publication status	Published - Apr 2004

Keywords

Bradycardia
Linezolid
Side effect

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Microbiology
Parasitology
Virology
Immunology and Allergy
Infectious Diseases

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10.1016/j.ijantimicag.2003.10.001

Cite this

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title = "Linezolid-induced bradycardia: A case report",

abstract = "We report an episode of severe bradycardia that occurred in a 49-year-old woman with fever and malignant jaundice during antibiotic therapy with linezolid, a new oxazolidinone with activity against Gram-positive cocci. In our case, the strict temporal dependence between bradycardia and linezolid therapy seems to provide strong evidence for a causal relationship. To our knowledge, this is the first report of linezolid-induced bradycardia. This adverse event confirms that the new antibiotic linezolid should be administered with caution in patient with jaundice and hepatic insufficiency.",

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T2 - A case report

AU - Tartarone, Alfredo

AU - Gallucci, Giuseppina

AU - Iodice, Giovanni

AU - Romano, Giampiero

AU - Coccaro, Mariarosa

AU - Vigliotti, Maria Luigia

AU - Mele, Giuseppe

AU - Matera, Rosella

AU - Di Renzo, Nicola

PY - 2004/4

Y1 - 2004/4

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AB - We report an episode of severe bradycardia that occurred in a 49-year-old woman with fever and malignant jaundice during antibiotic therapy with linezolid, a new oxazolidinone with activity against Gram-positive cocci. In our case, the strict temporal dependence between bradycardia and linezolid therapy seems to provide strong evidence for a causal relationship. To our knowledge, this is the first report of linezolid-induced bradycardia. This adverse event confirms that the new antibiotic linezolid should be administered with caution in patient with jaundice and hepatic insufficiency.

KW - Bradycardia

KW - Linezolid

KW - Side effect

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Linezolid-induced bradycardia: A case report

Abstract

Keywords

ASJC Scopus subject areas

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