Sepsi perinatale da staphylococcus aureus complicata da spondilodiscite ed endoftalmite e trattata con linezolid: Descrizione di un caso clinico

Translated title of the contribution: Linezolid therapy in a perinatal late-onset staphylococcus aureus sepsis complicated by spondylodiscitis and endophthalmitis

Research output: Contribution to journalArticle

Abstract

We report the case of a two-month-old immunocompetent girl affected by Staphylococcus aureus sepsis complicated with pneumonia and pleural effusion, spondylodiscitis and endophthalmitis treated with linezolid. She developed a S. aureus sepsis in the neonatal period antibiotically treated with clinical resolution. Ten days after therapy discontinuation, the infant experienced a new S. aureus sepsis complicated by pneumonia with pleural effusion. Due to the presence of dorsal swelling, a pulmonary computer tomography was performed that showed a dorsal D5-D6 spondylodiscitis. Since the sepsis was scarcely responsive to several appropriate antibiotics, we finally decided to treat the patient with linezolid. A few weeks after. changing antibiotics, the child underwent an ophthalmologic visit. Due to the finding of ocular lesions, imaging examinations were performed. The diagnosis was compatible with retinoblastoma, such that the eye was enucleated. Nevertheless, histological and microbiological investigations did not confirm the tumour hypothesis, but revealed a S. aureus abscess with retinal detachment. The child completed antibiotic therapy with linezolid and was visited periodically at the Infectious Disease Unit for a follow-up. She underwent progressive resolution of discitis and did not present any further flare of sepsis. Nevertheless, she still has a replacement device in her right eye and a D5-D6 severe kyphosis with spinal fusion.

Original languageItalian
Pages (from-to)353-357
Number of pages5
JournalInfezioni in Medicina
Volume23
Issue number4
Publication statusPublished - Dec 1 2015

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Linezolid
Discitis
Endophthalmitis
Staphylococcus aureus
Sepsis
Pleural Effusion
Anti-Bacterial Agents
Pneumonia
Spinal Fusion
Kyphosis
Retinoblastoma
Retinal Detachment
Therapeutics
Abscess
Communicable Diseases
Tomography
Equipment and Supplies
Lung

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Sepsi perinatale da staphylococcus aureus complicata da spondilodiscite ed endoftalmite e trattata con linezolid: Descrizione di un caso clinico",
abstract = "We report the case of a two-month-old immunocompetent girl affected by Staphylococcus aureus sepsis complicated with pneumonia and pleural effusion, spondylodiscitis and endophthalmitis treated with linezolid. She developed a S. aureus sepsis in the neonatal period antibiotically treated with clinical resolution. Ten days after therapy discontinuation, the infant experienced a new S. aureus sepsis complicated by pneumonia with pleural effusion. Due to the presence of dorsal swelling, a pulmonary computer tomography was performed that showed a dorsal D5-D6 spondylodiscitis. Since the sepsis was scarcely responsive to several appropriate antibiotics, we finally decided to treat the patient with linezolid. A few weeks after. changing antibiotics, the child underwent an ophthalmologic visit. Due to the finding of ocular lesions, imaging examinations were performed. The diagnosis was compatible with retinoblastoma, such that the eye was enucleated. Nevertheless, histological and microbiological investigations did not confirm the tumour hypothesis, but revealed a S. aureus abscess with retinal detachment. The child completed antibiotic therapy with linezolid and was visited periodically at the Infectious Disease Unit for a follow-up. She underwent progressive resolution of discitis and did not present any further flare of sepsis. Nevertheless, she still has a replacement device in her right eye and a D5-D6 severe kyphosis with spinal fusion.",
keywords = "Endophthalmitis, Linezolid, Sepsis, Spondylodiscitis, Staphylococcus aureus",
author = "Andrzej Krzysztofiak and Elena Bozzola and Laura Lancella and Elena Boccuzzi and Vittucci, {Anna Chiara} and Alessandra Marchesi and Alberto Villani",
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AU - Krzysztofiak, Andrzej

AU - Bozzola, Elena

AU - Lancella, Laura

AU - Boccuzzi, Elena

AU - Vittucci, Anna Chiara

AU - Marchesi, Alessandra

AU - Villani, Alberto

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