Linguistic, psychometric validation and diagnostic ability assessment of an Italian version of a 19-item wearing-off questionnaire for wearing-off detection in Parkinson's disease

Giovanni Abbruzzese, Angelo Antonini, Paolo Barone, Fabrizio Stocchi, Tiziano Tamburini, Laura Bernardi, Marianna Amboni, Laura Vacca, Valeria Posocco, Delia Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

A patient self-rated 19-item wearing-off questionnaire (WOQ-19) was shown to be a potent screening tool for wearing-off (WO) in patients with Parkinson's disease. As part of the early detection of wearing-off in Parkinson's disease study, we preliminarily performed a linguistic and a psychometric validation of an Italian version of the WOQ-19. Moreover, we assessed the sensitivity and specificity of the WOQ-19 in the office-based settings. The psychometric validation study included assessment of discriminant ability, internal consistency and test-retest reliability. The intraclass correlation coefficient (ICC) and the Cronbach's Alpha were assessed. The WOQ-19 sensitivity and specificity were calculated in respect to the physician assessment of WO, taken as the gold standard. The Italian version of WOQ-19 was found easy to understand by ≥80% of the patients. The number of WO-related symptoms detected by WOQ-19 was 7.5 ± 3.2 in patients with WO and 1.6 ± 2.6 in patients without WO (p

Original languageEnglish
Pages (from-to)1319-1327
Number of pages9
JournalNeurological Sciences
Volume33
Issue number6
DOIs
Publication statusPublished - Mar 23 2012

Keywords

  • Motor fluctuations
  • Non-motor fluctuations
  • Parkinson's disease
  • Wearing-off
  • Wearing-off patient questionnaire

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)

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