TY - JOUR
T1 - Linkage analysis does not support a role for glucokinase gene in the aetiology of type 2 diabetes mellitus among North Western Italians
AU - Laurino, C.
AU - Bertolinib, S.
AU - Cordera, R.
PY - 1994
Y1 - 1994
N2 - The contribution of a 3' glucokinase gene polymorphism to the aetiology of type 2 diabetes mellitus was studied in 17 diabetic pedigrees from North-Western Italy; linkage methodology was used. A CA repeat sequence was employed as a marker and amplified by PCR. Three alleles were found: Z (195 bp), Z + 4 (199 bp) and Z + 10 (205 bp). Since in diabetic families linkage analysis gave values of LOD score between -0.000438 and 0.026, the association between GK polymorphism and type 2 diabetes could not be either excluded or accepted. Based on these data, we conclude that glucokinase polymorphism is not a major determinant of type 2 diabetes mellitus, at least in our population, but, consistent with LOD score obtained, in some pedigrees it could assume a minor role in the aetiology of this disease.
AB - The contribution of a 3' glucokinase gene polymorphism to the aetiology of type 2 diabetes mellitus was studied in 17 diabetic pedigrees from North-Western Italy; linkage methodology was used. A CA repeat sequence was employed as a marker and amplified by PCR. Three alleles were found: Z (195 bp), Z + 4 (199 bp) and Z + 10 (205 bp). Since in diabetic families linkage analysis gave values of LOD score between -0.000438 and 0.026, the association between GK polymorphism and type 2 diabetes could not be either excluded or accepted. Based on these data, we conclude that glucokinase polymorphism is not a major determinant of type 2 diabetes mellitus, at least in our population, but, consistent with LOD score obtained, in some pedigrees it could assume a minor role in the aetiology of this disease.
KW - Genetics
KW - Glucokinase linkage
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0028070468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028070468&partnerID=8YFLogxK
U2 - 10.1016/0303-7207(94)90117-1
DO - 10.1016/0303-7207(94)90117-1
M3 - Article
C2 - 7988743
AN - SCOPUS:0028070468
VL - 104
SP - 147
EP - 151
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 2
ER -