Linkage analysis of the fragile X syndrome using a new DNA marker U6.2 defining locus DXS304

P. Goonewardena, W. T. Brown, A. C. Gross, C. Ferrando, C. Dobkin, V. Romano, P. Bosco, N. Ceratto, U. Pettersson, N. Dahl

Research output: Contribution to journalArticle

Abstract

A new RFLP marker U6.2 defining the locus DXS304 was recently mapped to the distal long arm of the X chromosome. In the present study we report the results of genetic linkage analysis of 13 fragile X [fra(X)] families that were informative for the new marker. Analysis of the recombinants for F9-FRAXA, DXS105-FRAXA, DXS98-FRAXA, DXS52-FRAXA, DXS15-FRAXA, and F8C-FRAXA, places DXS304 distal and near to the FRAXA locus. Combined with results from previous studies, our results support the order Xcen.-F9-DXS105-DXS98-FRAXA-DXS304-DXS52-DXS15-F8C-Xqter. Close linkage was observed between DXS304 and the disease locus with a peak lod score of 5.12 at Θ = 0.04 from the present study and, with a peak lod score of 17.45 at Θ = 0.035 when our data are combined with published data from 2 other studies. The present study confirms that U6.2 is useful for prenatal diagnosis and carrier testing in families affected by fra(X) syndrome.

Original languageEnglish
Pages (from-to)322-327
Number of pages6
JournalAmerican Journal of Medical Genetics
Volume38
Issue number2-3
DOIs
Publication statusPublished - 1991

Fingerprint

Lod Score
Fragile X Syndrome
Genetic Markers
Genetic Linkage
X Chromosome
Prenatal Diagnosis
Restriction Fragment Length Polymorphisms

Keywords

  • DNA markers
  • genetic linkage
  • RFLPs

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Goonewardena, P., Brown, W. T., Gross, A. C., Ferrando, C., Dobkin, C., Romano, V., ... Dahl, N. (1991). Linkage analysis of the fragile X syndrome using a new DNA marker U6.2 defining locus DXS304. American Journal of Medical Genetics, 38(2-3), 322-327. https://doi.org/10.1002/ajmg.1320380231

Linkage analysis of the fragile X syndrome using a new DNA marker U6.2 defining locus DXS304. / Goonewardena, P.; Brown, W. T.; Gross, A. C.; Ferrando, C.; Dobkin, C.; Romano, V.; Bosco, P.; Ceratto, N.; Pettersson, U.; Dahl, N.

In: American Journal of Medical Genetics, Vol. 38, No. 2-3, 1991, p. 322-327.

Research output: Contribution to journalArticle

Goonewardena, P, Brown, WT, Gross, AC, Ferrando, C, Dobkin, C, Romano, V, Bosco, P, Ceratto, N, Pettersson, U & Dahl, N 1991, 'Linkage analysis of the fragile X syndrome using a new DNA marker U6.2 defining locus DXS304', American Journal of Medical Genetics, vol. 38, no. 2-3, pp. 322-327. https://doi.org/10.1002/ajmg.1320380231
Goonewardena, P. ; Brown, W. T. ; Gross, A. C. ; Ferrando, C. ; Dobkin, C. ; Romano, V. ; Bosco, P. ; Ceratto, N. ; Pettersson, U. ; Dahl, N. / Linkage analysis of the fragile X syndrome using a new DNA marker U6.2 defining locus DXS304. In: American Journal of Medical Genetics. 1991 ; Vol. 38, No. 2-3. pp. 322-327.
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