Linkage disequilibrium and haplotype mapping of a skin cancer susceptibility locus in outbred mice

Bernard Peissel; Daniela Zaffaroni; Nicola Zanesi; Ignazio Zedda; Giacomo Manenti; Simonetta Rebessi; Simonetta Pazzaglia; Gino Doria; Vincenzo Covelli; Tommaso A. Dragani; Anna Saran

Linkage disequilibrium and haplotype mapping of a skin cancer susceptibility locus in outbred mice

Bernard Peissel, Daniela Zaffaroni, Nicola Zanesi, Ignazio Zedda, Giacomo Manenti, Simonetta Rebessi, Simonetta Pazzaglia, Gino Doria, Vincenzo Covelli, Tommaso A. Dragani, Anna Saran

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Car-R (carcinogenesis-resistant) and Car-S (carcinogenesis-susceptible) outbred mice, obtained by phenotypic selection from an initial intercross of eight inbred strains, show a >100fold difference in their susceptibility to two-stage skin tumorigenesis. We found that the lines carry a high degree of genetic polymorphism, with an average heterozygosity of 0.39. This polymorphism allowed the use of linkage disequilibrium (LD) and haplotype analysis for the mapping of a skin cancer modifier locus on Chr 7, in a short region of 6 cM, around the Tyr gene. Car-S mice inherited the susceptibility allele at this locus from the A/J, BALB/c, SJL/J, and SWR/J strains. Our results demonstrate the feasibility and usefulness of mapping disease genes by LD in phenotypically selected, genetically heterogeneous animals.

Original language	English
Pages (from-to)	979-981
Number of pages	3
Journal	Mammalian Genome
Volume	11
Issue number	11
Publication status	Published - 2000

ASJC Scopus subject areas

Genetics

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Linkage disequilibrium and haplotype mapping of a skin cancer susceptibility locus in outbred mice. / Peissel, Bernard; Zaffaroni, Daniela; Zanesi, Nicola; Zedda, Ignazio; Manenti, Giacomo; Rebessi, Simonetta; Pazzaglia, Simonetta; Doria, Gino; Covelli, Vincenzo; Dragani, Tommaso A.; Saran, Anna.

In: Mammalian Genome, Vol. 11, No. 11, 2000, p. 979-981.

Research output: Contribution to journal › Article › peer-review

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abstract = "Car-R (carcinogenesis-resistant) and Car-S (carcinogenesis-susceptible) outbred mice, obtained by phenotypic selection from an initial intercross of eight inbred strains, show a >100fold difference in their susceptibility to two-stage skin tumorigenesis. We found that the lines carry a high degree of genetic polymorphism, with an average heterozygosity of 0.39. This polymorphism allowed the use of linkage disequilibrium (LD) and haplotype analysis for the mapping of a skin cancer modifier locus on Chr 7, in a short region of 6 cM, around the Tyr gene. Car-S mice inherited the susceptibility allele at this locus from the A/J, BALB/c, SJL/J, and SWR/J strains. Our results demonstrate the feasibility and usefulness of mapping disease genes by LD in phenotypically selected, genetically heterogeneous animals.",

author = "Bernard Peissel and Daniela Zaffaroni and Nicola Zanesi and Ignazio Zedda and Giacomo Manenti and Simonetta Rebessi and Simonetta Pazzaglia and Gino Doria and Vincenzo Covelli and Dragani, {Tommaso A.} and Anna Saran",

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AU - Peissel, Bernard

AU - Zaffaroni, Daniela

AU - Zanesi, Nicola

AU - Zedda, Ignazio

AU - Manenti, Giacomo

AU - Rebessi, Simonetta

AU - Pazzaglia, Simonetta

AU - Doria, Gino

AU - Covelli, Vincenzo

AU - Dragani, Tommaso A.

AU - Saran, Anna

PY - 2000

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N2 - Car-R (carcinogenesis-resistant) and Car-S (carcinogenesis-susceptible) outbred mice, obtained by phenotypic selection from an initial intercross of eight inbred strains, show a >100fold difference in their susceptibility to two-stage skin tumorigenesis. We found that the lines carry a high degree of genetic polymorphism, with an average heterozygosity of 0.39. This polymorphism allowed the use of linkage disequilibrium (LD) and haplotype analysis for the mapping of a skin cancer modifier locus on Chr 7, in a short region of 6 cM, around the Tyr gene. Car-S mice inherited the susceptibility allele at this locus from the A/J, BALB/c, SJL/J, and SWR/J strains. Our results demonstrate the feasibility and usefulness of mapping disease genes by LD in phenotypically selected, genetically heterogeneous animals.

AB - Car-R (carcinogenesis-resistant) and Car-S (carcinogenesis-susceptible) outbred mice, obtained by phenotypic selection from an initial intercross of eight inbred strains, show a >100fold difference in their susceptibility to two-stage skin tumorigenesis. We found that the lines carry a high degree of genetic polymorphism, with an average heterozygosity of 0.39. This polymorphism allowed the use of linkage disequilibrium (LD) and haplotype analysis for the mapping of a skin cancer modifier locus on Chr 7, in a short region of 6 cM, around the Tyr gene. Car-S mice inherited the susceptibility allele at this locus from the A/J, BALB/c, SJL/J, and SWR/J strains. Our results demonstrate the feasibility and usefulness of mapping disease genes by LD in phenotypically selected, genetically heterogeneous animals.

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