Linkage disequilibrium pattern in the L-myc gene in Italian and Japanese non-small-cell lung-cancer patients

Monica Spinola, Tomoko Nomoto, Giacomo Manenti, F. Stefania Falvella, Pier Paolo Brega Massone, Barbara Conti, Ignazio Cataldo, Pinuccia Valagussa, Matteo Incarbone, Kazuaki Miyamoto, Toshikazu Ushijima, Tommaso A. Dragani

Research output: Contribution to journalArticle

Abstract

Italian and Japanese non-small-cell lung-cancer patients were genotyped for an intragenic L-myc EcoRI restriction site polymorphism previously reported to be associated with lung-tumor prognosis in Asian populations but not in Caucasians. Screening of the L-myc sequence in Italian samples allowed identification of 2 additional 3′-UTR SNPs, located 2.3-3.0 kb from the EcoRI polymorphism, but no coding polymorphism was found. No significant association was found between any of the 3 SNPs and lung-tumor prognosis in Italian patients, consistent with the reported difference between Caucasian and Asian populations. Moreover, the newly discovered polymorphisms in the Italian group were not present in Japanese patients. Significant LD between EcoRI and the 2 other SNPs was detected in the Italian population, whereas no significant LD between the 2 3′-UTR markers was detected despite their close proximity (0.7 kb). Thus, the disparate conclusions about the role of L-myc polymorphism in tumor prognosis among different populations may rest in population-specific LD between the functional gene and the L-myc polymorphism.

Original languageEnglish
Pages (from-to)329-331
Number of pages3
JournalInternational Journal of Cancer
Volume95
Issue number5
DOIs
Publication statusPublished - Sep 20 2001

Keywords

  • Allele frequency
  • Cancer susceptibility
  • Disease association
  • Genetic polymorphisms
  • SNPs

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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