TY - JOUR
T1 - Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity
AU - Ahmad, Wasim
AU - De Fusco, Maurizio
AU - Ul Haque, Muhammad Faiyaz
AU - Aridon, Paolo
AU - Sarno, Tiziana
AU - Sohail, Muhammad
AU - Ul Haque, Sayed Ul
AU - Ahmad, Mahmud
AU - Ballabio, Andrea
AU - Franco, Brunella
AU - Casari, Giorgio
PY - 1999/10
Y1 - 1999/10
N2 - A new syndromic form of X-linked mental retardation associated to obesity, MRXS7, has been localised to Xp11.3-Xq23 in a large Pakistani family. The ten affected males show clinical manifestations of mental retardation, obesity and hypogonadism. The family was genotyped by a set of microsatellite markers spaced at approximately 10 cM intervals on the X chromosome. Linkage to five adjacent microsatellite markers, mapping in the pericentromeric area, was established and a maximum two-point lod score of 3.86 was reached at zero recombination with marker DXS1106. Reduced recombination events around the centromere prevented precise mapping of the gene.
AB - A new syndromic form of X-linked mental retardation associated to obesity, MRXS7, has been localised to Xp11.3-Xq23 in a large Pakistani family. The ten affected males show clinical manifestations of mental retardation, obesity and hypogonadism. The family was genotyped by a set of microsatellite markers spaced at approximately 10 cM intervals on the X chromosome. Linkage to five adjacent microsatellite markers, mapping in the pericentromeric area, was established and a maximum two-point lod score of 3.86 was reached at zero recombination with marker DXS1106. Reduced recombination events around the centromere prevented precise mapping of the gene.
KW - Linkage mapping
KW - Obesity
KW - X-linked mental retardation
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U2 - 10.1038/sj.ejhg.5200376
DO - 10.1038/sj.ejhg.5200376
M3 - Article
C2 - 10573017
AN - SCOPUS:0032727076
VL - 7
SP - 828
EP - 832
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
SN - 1018-4813
IS - 7
ER -