Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity

Wasim Ahmad, Maurizio De Fusco, Muhammad Faiyaz Ul Haque, Paolo Aridon, Tiziana Sarno, Muhammad Sohail, Sayed Ul Ul Haque, Mahmud Ahmad, Andrea Ballabio, Brunella Franco, Giorgio Casari

Research output: Contribution to journalArticlepeer-review

Abstract

A new syndromic form of X-linked mental retardation associated to obesity, MRXS7, has been localised to Xp11.3-Xq23 in a large Pakistani family. The ten affected males show clinical manifestations of mental retardation, obesity and hypogonadism. The family was genotyped by a set of microsatellite markers spaced at approximately 10 cM intervals on the X chromosome. Linkage to five adjacent microsatellite markers, mapping in the pericentromeric area, was established and a maximum two-point lod score of 3.86 was reached at zero recombination with marker DXS1106. Reduced recombination events around the centromere prevented precise mapping of the gene.

Original languageEnglish
Pages (from-to)828-832
Number of pages5
JournalEuropean Journal of Human Genetics
Volume7
Issue number7
DOIs
Publication statusPublished - Oct 1999

Keywords

  • Linkage mapping
  • Obesity
  • X-linked mental retardation

ASJC Scopus subject areas

  • Genetics(clinical)

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