Linkage mapping of benign familial infantile convulsions (BFIC) to chromosome 19q

Michel Guipponi, François Rivier, Federico Vigevano, Corinne Beck, Arielle Crespel, Bernard Echenne, Pierpaolo Lucchini, Rosella Sebastianelli, Michel Baldy-Moulinier, Alain Malafosse

Research output: Contribution to journalArticlepeer-review

Abstract

Benign familial infantile convulsions (BFIC) are an autosomal-dominant epileptic syndrome characterized by an age of onset within the first year of life. Although they were first reported in families of Italian descent, BFIC have also been described in non-italian families. We have mapped the BFIC gene to chromosome 19 by linkage analysis in five Italian families with a maximum two-point lod score of 6.36 at D19S114; maximum multipoint lod scores > 8 were obtained for the interval D19S250-D19S245. BFIC are therefore the third idiopathic partial epileptic syndrome to be mapped on the human genome.

Original languageEnglish
Pages (from-to)473-477
Number of pages5
JournalHuman Molecular Genetics
Volume6
Issue number3
DOIs
Publication statusPublished - Mar 1997

ASJC Scopus subject areas

  • Genetics

Fingerprint

Dive into the research topics of 'Linkage mapping of benign familial infantile convulsions (BFIC) to chromosome 19q'. Together they form a unique fingerprint.

Cite this