Linkage of familial dilated cardiomyopathy to chromosome 9

M. Krajinovic, B. Pinamonti, G. Sinagra, M. Vatta, G. M. Severini, J. Milasin, A. Falaschi, F. Camerini, M. Giacca, L. Mestroni, A. Di Lenarda, G. Lardieri, T. Morgera, F. Silvestri, R. Bussani, M. Davanzo, G. Meringolo

Research output: Contribution to journalArticle

Abstract

Idiopathic dilated cardiomyopathy is a heart muscle disease of unknown etiology, characterized by impaired myocardial contractility and ventricular dilatation. The disorder is an important cause of morbidity and mortality and represents the chief indication for heart transplantation. Familial transmission is often recognized (familial dilated cardiomyopathy, or FDC), mostly with autosomal dominant inheritance. In order to understand the molecular genetic basis of the disease, a large six-generation kindred with autosomal dominant FDC was studied for linkage analysis. A genome-wide search was undertaken after a large series of candidate genes were excluded and was then extended to two other families with autosomal dominant pattern of transmission and identical clinical features. Coinheritance of the disease gene was excluded for >95% of the genome, after 251 polymorphic markers were analyzed. Linkage was found for chromosome 9q13-q22, with a maximum multipoint lod score of 4.2. There was no evidence of heterogeneity. The FDC locus was placed in the interval between loci D9S153 and D9S152. Several candidate genes for causing dilated cardiomyopathy map in this region.

Original languageEnglish
Pages (from-to)846-852
Number of pages7
JournalAmerican Journal of Human Genetics
Volume57
Issue number4
Publication statusPublished - 1995

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Chromosomes, Human, Pair 9
Dilated Cardiomyopathy
Genome
Genes
Lod Score
Inborn Genetic Diseases
Heart Transplantation
Molecular Biology
Dilatation
Heart Diseases
Myocardium
Chromosomes
Morbidity
Mortality
Familial dilated cardiomyopathy

ASJC Scopus subject areas

  • Genetics

Cite this

Krajinovic, M., Pinamonti, B., Sinagra, G., Vatta, M., Severini, G. M., Milasin, J., ... Meringolo, G. (1995). Linkage of familial dilated cardiomyopathy to chromosome 9. American Journal of Human Genetics, 57(4), 846-852.

Linkage of familial dilated cardiomyopathy to chromosome 9. / Krajinovic, M.; Pinamonti, B.; Sinagra, G.; Vatta, M.; Severini, G. M.; Milasin, J.; Falaschi, A.; Camerini, F.; Giacca, M.; Mestroni, L.; Di Lenarda, A.; Lardieri, G.; Morgera, T.; Silvestri, F.; Bussani, R.; Davanzo, M.; Meringolo, G.

In: American Journal of Human Genetics, Vol. 57, No. 4, 1995, p. 846-852.

Research output: Contribution to journalArticle

Krajinovic, M, Pinamonti, B, Sinagra, G, Vatta, M, Severini, GM, Milasin, J, Falaschi, A, Camerini, F, Giacca, M, Mestroni, L, Di Lenarda, A, Lardieri, G, Morgera, T, Silvestri, F, Bussani, R, Davanzo, M & Meringolo, G 1995, 'Linkage of familial dilated cardiomyopathy to chromosome 9', American Journal of Human Genetics, vol. 57, no. 4, pp. 846-852.
Krajinovic M, Pinamonti B, Sinagra G, Vatta M, Severini GM, Milasin J et al. Linkage of familial dilated cardiomyopathy to chromosome 9. American Journal of Human Genetics. 1995;57(4):846-852.
Krajinovic, M. ; Pinamonti, B. ; Sinagra, G. ; Vatta, M. ; Severini, G. M. ; Milasin, J. ; Falaschi, A. ; Camerini, F. ; Giacca, M. ; Mestroni, L. ; Di Lenarda, A. ; Lardieri, G. ; Morgera, T. ; Silvestri, F. ; Bussani, R. ; Davanzo, M. ; Meringolo, G. / Linkage of familial dilated cardiomyopathy to chromosome 9. In: American Journal of Human Genetics. 1995 ; Vol. 57, No. 4. pp. 846-852.
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AU - Vatta, M.

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AU - Milasin, J.

AU - Falaschi, A.

AU - Camerini, F.

AU - Giacca, M.

AU - Mestroni, L.

AU - Di Lenarda, A.

AU - Lardieri, G.

AU - Morgera, T.

AU - Silvestri, F.

AU - Bussani, R.

AU - Davanzo, M.

AU - Meringolo, G.

PY - 1995

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N2 - Idiopathic dilated cardiomyopathy is a heart muscle disease of unknown etiology, characterized by impaired myocardial contractility and ventricular dilatation. The disorder is an important cause of morbidity and mortality and represents the chief indication for heart transplantation. Familial transmission is often recognized (familial dilated cardiomyopathy, or FDC), mostly with autosomal dominant inheritance. In order to understand the molecular genetic basis of the disease, a large six-generation kindred with autosomal dominant FDC was studied for linkage analysis. A genome-wide search was undertaken after a large series of candidate genes were excluded and was then extended to two other families with autosomal dominant pattern of transmission and identical clinical features. Coinheritance of the disease gene was excluded for >95% of the genome, after 251 polymorphic markers were analyzed. Linkage was found for chromosome 9q13-q22, with a maximum multipoint lod score of 4.2. There was no evidence of heterogeneity. The FDC locus was placed in the interval between loci D9S153 and D9S152. Several candidate genes for causing dilated cardiomyopathy map in this region.

AB - Idiopathic dilated cardiomyopathy is a heart muscle disease of unknown etiology, characterized by impaired myocardial contractility and ventricular dilatation. The disorder is an important cause of morbidity and mortality and represents the chief indication for heart transplantation. Familial transmission is often recognized (familial dilated cardiomyopathy, or FDC), mostly with autosomal dominant inheritance. In order to understand the molecular genetic basis of the disease, a large six-generation kindred with autosomal dominant FDC was studied for linkage analysis. A genome-wide search was undertaken after a large series of candidate genes were excluded and was then extended to two other families with autosomal dominant pattern of transmission and identical clinical features. Coinheritance of the disease gene was excluded for >95% of the genome, after 251 polymorphic markers were analyzed. Linkage was found for chromosome 9q13-q22, with a maximum multipoint lod score of 4.2. There was no evidence of heterogeneity. The FDC locus was placed in the interval between loci D9S153 and D9S152. Several candidate genes for causing dilated cardiomyopathy map in this region.

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