Abstract
Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 51-61 |
| Number of pages | 11 |
| Journal | Journal of Affective Disorders |
| Volume | 58 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 2000 |
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Keywords
- Bipolar disorder
- Dopamine receptors
- DRD2
- DRD3
- Linkage
- Tyrosine hydroxylase
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
Linkage of mood disorders with D2, D3 and TH genes : A multicenter study. / Serretti, A.; Macciardi, F.; Cusin, C.; Lattuada, E.; Souery, D.; Lipp, O.; Mahieu, B.; Van Broeckhoven, C.; Blackwood, D.; Muir, W.; Aschauer, H. N.; Heiden, A. M.; Ackenheil, M.; Fuchshuber, S.; Raeymaekers, P.; Verheyen, G.; Kaneva, R.; Jablensky, A.; Papadimitriou, G. N.; Dikeos, D. G.; Stefanis, C. N.; Smeraldi, E.; Mendlewicz, J.
In: Journal of Affective Disorders, Vol. 58, No. 1, 04.2000, p. 51-61.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Linkage of mood disorders with D2, D3 and TH genes
T2 - A multicenter study
AU - Serretti, A.
AU - Macciardi, F.
AU - Cusin, C.
AU - Lattuada, E.
AU - Souery, D.
AU - Lipp, O.
AU - Mahieu, B.
AU - Van Broeckhoven, C.
AU - Blackwood, D.
AU - Muir, W.
AU - Aschauer, H. N.
AU - Heiden, A. M.
AU - Ackenheil, M.
AU - Fuchshuber, S.
AU - Raeymaekers, P.
AU - Verheyen, G.
AU - Kaneva, R.
AU - Jablensky, A.
AU - Papadimitriou, G. N.
AU - Dikeos, D. G.
AU - Stefanis, C. N.
AU - Smeraldi, E.
AU - Mendlewicz, J.
PY - 2000/4
Y1 - 2000/4
N2 - Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.
AB - Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.
KW - Bipolar disorder
KW - Dopamine receptors
KW - DRD2
KW - DRD3
KW - Linkage
KW - Tyrosine hydroxylase
UR - http://www.scopus.com/inward/record.url?scp=0034177796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034177796&partnerID=8YFLogxK
U2 - 10.1016/S0165-0327(99)00112-3
DO - 10.1016/S0165-0327(99)00112-3
M3 - Article
C2 - 10760558
AN - SCOPUS:0034177796
VL - 58
SP - 51
EP - 61
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1
ER -