Linkage of mood disorders with D2, D3 and TH genes: A multicenter study

A. Serretti; F. Macciardi; C. Cusin; E. Lattuada; D. Souery; O. Lipp; B. Mahieu; C. Van Broeckhoven; D. Blackwood; W. Muir; H. N. Aschauer; A. M. Heiden; M. Ackenheil; S. Fuchshuber; P. Raeymaekers; G. Verheyen; R. Kaneva; A. Jablensky; G. N. Papadimitriou; D. G. Dikeos; C. N. Stefanis; E. Smeraldi; J. Mendlewicz

doi:10.1016/S0165-0327(99)00112-3

Linkage of mood disorders with D2, D3 and TH genes: A multicenter study

A. Serretti, F. Macciardi, C. Cusin, E. Lattuada, D. Souery, O. Lipp, B. Mahieu, C. Van Broeckhoven, D. Blackwood, W. Muir, H. N. Aschauer, A. M. Heiden, M. Ackenheil, S. Fuchshuber, P. Raeymaekers, G. Verheyen, R. Kaneva, A. Jablensky, G. N. Papadimitriou, D. G. DikeosC. N. Stefanis, E. Smeraldi, J. Mendlewicz

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	51-61
Number of pages	11
Journal	Journal of Affective Disorders
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/S0165-0327(99)00112-3
Publication status	Published - Apr 2000

Keywords

Bipolar disorder
Dopamine receptors
DRD2
DRD3
Linkage
Tyrosine hydroxylase

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

Access to Document

10.1016/S0165-0327(99)00112-3

Fingerprint Dive into the research topics of 'Linkage of mood disorders with D2, D3 and TH genes: A multicenter study'. Together they form a unique fingerprint.

Cite this

Serretti, A., Macciardi, F., Cusin, C., Lattuada, E., Souery, D., Lipp, O., Mahieu, B., Van Broeckhoven, C., Blackwood, D., Muir, W., Aschauer, H. N., Heiden, A. M., Ackenheil, M., Fuchshuber, S., Raeymaekers, P., Verheyen, G., Kaneva, R., Jablensky, A., Papadimitriou, G. N., ... Mendlewicz, J. (2000). Linkage of mood disorders with D2, D3 and TH genes: A multicenter study. Journal of Affective Disorders, 58(1), 51-61. https://doi.org/10.1016/S0165-0327(99)00112-3

Linkage of mood disorders with D2, D3 and TH genes : A multicenter study. / Serretti, A.; Macciardi, F.; Cusin, C.; Lattuada, E.; Souery, D.; Lipp, O.; Mahieu, B.; Van Broeckhoven, C.; Blackwood, D.; Muir, W.; Aschauer, H. N.; Heiden, A. M.; Ackenheil, M.; Fuchshuber, S.; Raeymaekers, P.; Verheyen, G.; Kaneva, R.; Jablensky, A.; Papadimitriou, G. N.; Dikeos, D. G.; Stefanis, C. N.; Smeraldi, E.; Mendlewicz, J.

In: Journal of Affective Disorders, Vol. 58, No. 1, 04.2000, p. 51-61.

Research output: Contribution to journal › Article › peer-review

Serretti, A, Macciardi, F, Cusin, C, Lattuada, E, Souery, D, Lipp, O, Mahieu, B, Van Broeckhoven, C, Blackwood, D, Muir, W, Aschauer, HN, Heiden, AM, Ackenheil, M, Fuchshuber, S, Raeymaekers, P, Verheyen, G, Kaneva, R, Jablensky, A, Papadimitriou, GN, Dikeos, DG, Stefanis, CN, Smeraldi, E & Mendlewicz, J 2000, 'Linkage of mood disorders with D2, D3 and TH genes: A multicenter study', Journal of Affective Disorders, vol. 58, no. 1, pp. 51-61. https://doi.org/10.1016/S0165-0327(99)00112-3

Serretti, A. ; Macciardi, F. ; Cusin, C. ; Lattuada, E. ; Souery, D. ; Lipp, O. ; Mahieu, B. ; Van Broeckhoven, C. ; Blackwood, D. ; Muir, W. ; Aschauer, H. N. ; Heiden, A. M. ; Ackenheil, M. ; Fuchshuber, S. ; Raeymaekers, P. ; Verheyen, G. ; Kaneva, R. ; Jablensky, A. ; Papadimitriou, G. N. ; Dikeos, D. G. ; Stefanis, C. N. ; Smeraldi, E. ; Mendlewicz, J. / Linkage of mood disorders with D2, D3 and TH genes : A multicenter study. In: Journal of Affective Disorders. 2000 ; Vol. 58, No. 1. pp. 51-61.

@article{a86796ea3dbc4cdd91b0f5cee119d93b,

title = "Linkage of mood disorders with D2, D3 and TH genes: A multicenter study",

abstract = "Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.",

keywords = "Bipolar disorder, Dopamine receptors, DRD2, DRD3, Linkage, Tyrosine hydroxylase",

author = "A. Serretti and F. Macciardi and C. Cusin and E. Lattuada and D. Souery and O. Lipp and B. Mahieu and {Van Broeckhoven}, C. and D. Blackwood and W. Muir and Aschauer, {H. N.} and Heiden, {A. M.} and M. Ackenheil and S. Fuchshuber and P. Raeymaekers and G. Verheyen and R. Kaneva and A. Jablensky and Papadimitriou, {G. N.} and Dikeos, {D. G.} and Stefanis, {C. N.} and E. Smeraldi and J. Mendlewicz",

year = "2000",

month = apr,

doi = "10.1016/S0165-0327(99)00112-3",

language = "English",

volume = "58",

pages = "51--61",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Linkage of mood disorders with D2, D3 and TH genes

T2 - A multicenter study

AU - Serretti, A.

AU - Macciardi, F.

AU - Cusin, C.

AU - Lattuada, E.

AU - Souery, D.

AU - Lipp, O.

AU - Mahieu, B.

AU - Van Broeckhoven, C.

AU - Blackwood, D.

AU - Muir, W.

AU - Aschauer, H. N.

AU - Heiden, A. M.

AU - Ackenheil, M.

AU - Fuchshuber, S.

AU - Raeymaekers, P.

AU - Verheyen, G.

AU - Kaneva, R.

AU - Jablensky, A.

AU - Papadimitriou, G. N.

AU - Dikeos, D. G.

AU - Stefanis, C. N.

AU - Smeraldi, E.

AU - Mendlewicz, J.

PY - 2000/4

Y1 - 2000/4

N2 - Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.

AB - Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.

KW - Bipolar disorder

KW - Dopamine receptors

KW - DRD2

KW - DRD3

KW - Linkage

KW - Tyrosine hydroxylase

UR - http://www.scopus.com/inward/record.url?scp=0034177796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034177796&partnerID=8YFLogxK

U2 - 10.1016/S0165-0327(99)00112-3

DO - 10.1016/S0165-0327(99)00112-3

M3 - Article

C2 - 10760558

AN - SCOPUS:0034177796

VL - 58

SP - 51

EP - 61

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1

ER -