Linkage of mood disorders with D2, D3 and TH genes: A multicenter study

A. Serretti; F. Macciardi; C. Cusin; E. Lattuada; D. Souery; O. Lipp; B. Mahieu; C. Van Broeckhoven; D. Blackwood; W. Muir; H. N. Aschauer; A. M. Heiden; M. Ackenheil; S. Fuchshuber; P. Raeymaekers; G. Verheyen; R. Kaneva; A. Jablensky; G. N. Papadimitriou; D. G. Dikeos; C. N. Stefanis; E. Smeraldi; J. Mendlewicz

doi:10.1016/S0165-0327(99)00112-3

Linkage of mood disorders with D2, D3 and TH genes: A multicenter study

A. Serretti, F. Macciardi, C. Cusin, E. Lattuada, D. Souery, O. Lipp, B. Mahieu, C. Van Broeckhoven, D. Blackwood, W. Muir, H. N. Aschauer, A. M. Heiden, M. Ackenheil, S. Fuchshuber, P. Raeymaekers, G. Verheyen, R. Kaneva, A. Jablensky, G. N. Papadimitriou, D. G. DikeosC. N. Stefanis, E. Smeraldi, J. Mendlewicz

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	51-61
Number of pages	11
Journal	Journal of Affective Disorders
Volume	58
Issue number	1
DOIs	https://doi.org/10.1016/S0165-0327(99)00112-3
Publication status	Published - Apr 2000

Keywords

Bipolar disorder
Dopamine receptors
DRD2
DRD3
Linkage
Tyrosine hydroxylase

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

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10.1016/S0165-0327(99)00112-3

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Serretti, A., Macciardi, F., Cusin, C., Lattuada, E., Souery, D., Lipp, O., Mahieu, B., Van Broeckhoven, C., Blackwood, D., Muir, W., Aschauer, H. N., Heiden, A. M., Ackenheil, M., Fuchshuber, S., Raeymaekers, P., Verheyen, G., Kaneva, R., Jablensky, A., Papadimitriou, G. N., ... Mendlewicz, J. (2000). Linkage of mood disorders with D2, D3 and TH genes: A multicenter study. Journal of Affective Disorders, 58(1), 51-61. https://doi.org/10.1016/S0165-0327(99)00112-3

Linkage of mood disorders with D2, D3 and TH genes : A multicenter study. / Serretti, A.; Macciardi, F.; Cusin, C.; Lattuada, E.; Souery, D.; Lipp, O.; Mahieu, B.; Van Broeckhoven, C.; Blackwood, D.; Muir, W.; Aschauer, H. N.; Heiden, A. M.; Ackenheil, M.; Fuchshuber, S.; Raeymaekers, P.; Verheyen, G.; Kaneva, R.; Jablensky, A.; Papadimitriou, G. N.; Dikeos, D. G.; Stefanis, C. N.; Smeraldi, E.; Mendlewicz, J.

In: Journal of Affective Disorders, Vol. 58, No. 1, 04.2000, p. 51-61.

Research output: Contribution to journal › Article › peer-review

Serretti, A, Macciardi, F, Cusin, C, Lattuada, E, Souery, D, Lipp, O, Mahieu, B, Van Broeckhoven, C, Blackwood, D, Muir, W, Aschauer, HN, Heiden, AM, Ackenheil, M, Fuchshuber, S, Raeymaekers, P, Verheyen, G, Kaneva, R, Jablensky, A, Papadimitriou, GN, Dikeos, DG, Stefanis, CN, Smeraldi, E & Mendlewicz, J 2000, 'Linkage of mood disorders with D2, D3 and TH genes: A multicenter study', Journal of Affective Disorders, vol. 58, no. 1, pp. 51-61. https://doi.org/10.1016/S0165-0327(99)00112-3

Serretti, A. ; Macciardi, F. ; Cusin, C. ; Lattuada, E. ; Souery, D. ; Lipp, O. ; Mahieu, B. ; Van Broeckhoven, C. ; Blackwood, D. ; Muir, W. ; Aschauer, H. N. ; Heiden, A. M. ; Ackenheil, M. ; Fuchshuber, S. ; Raeymaekers, P. ; Verheyen, G. ; Kaneva, R. ; Jablensky, A. ; Papadimitriou, G. N. ; Dikeos, D. G. ; Stefanis, C. N. ; Smeraldi, E. ; Mendlewicz, J. / Linkage of mood disorders with D2, D3 and TH genes : A multicenter study. In: Journal of Affective Disorders. 2000 ; Vol. 58, No. 1. pp. 51-61.

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abstract = "Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.",

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T2 - A multicenter study

AU - Serretti, A.

AU - Macciardi, F.

AU - Cusin, C.

AU - Lattuada, E.

AU - Souery, D.

AU - Lipp, O.

AU - Mahieu, B.

AU - Van Broeckhoven, C.

AU - Blackwood, D.

AU - Muir, W.

AU - Aschauer, H. N.

AU - Heiden, A. M.

AU - Ackenheil, M.

AU - Fuchshuber, S.

AU - Raeymaekers, P.

AU - Verheyen, G.

AU - Kaneva, R.

AU - Jablensky, A.

AU - Papadimitriou, G. N.

AU - Dikeos, D. G.

AU - Stefanis, C. N.

AU - Smeraldi, E.

AU - Mendlewicz, J.

PY - 2000/4

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N2 - Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.

AB - Background: It has been suggested that the dopaminergic system is involved in the pathophysiology of mood disorders. We conducted a multicenter study of families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Various potential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar+major depressive+schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkage for all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. Copyright (C) 2000 Elsevier Science B.V.

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KW - Dopamine receptors

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KW - DRD3

KW - Linkage

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Linkage of mood disorders with D2, D3 and TH genes: A multicenter study

Abstract

Keywords

ASJC Scopus subject areas

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