Abstract
The early peak of relapse in patients with breast carcinomas that overexpress HER2 oncoprotein and dissemination to the axillary lymph nodes might be related to proliferation of micrometastatic lesions induced by EGF family growth factors released at the time of surgery. If the levels of these growth factors have an impact on relapse, the survival of patients with positive nodes and HER2-positive tumours should be dependent on surgery wideness. To test this hypothesis, HER2 status of primary tumours from patients included in a randomized clinical trial addressing conservative quadrantectomy versus radical mastectomy was retrospectively analyzed. In HER2-negative patients, independently of node infiltration, and in HER2-positive patients without node infiltration, no differences in survival according to the type of surgery were observed. In patients with positive nodes and HER2-positive tumours the estimation of the time-dependent log-hazard ratios showed that radical mastectomy significantly increased early death rates (P = 0.037).
| Original language | English |
|---|---|
| Pages (from-to) | 1057-1061 |
| Number of pages | 5 |
| Journal | European Journal of Cancer |
| Volume | 42 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - May 2006 |
Fingerprint
Keywords
- Breast cancer
- HER2
- Surgery
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Linking survival of HER2-positive breast carcinoma patients with surgical invasiveness. / Tagliabue, Elda; Agresti, Roberto; Casalini, Patrizia; Mariani, Luigi; Carcangiu, Maria Luisa; Balsari, Andrea; Veronesi, Umberto; Ménard, Sylvie.
In: European Journal of Cancer, Vol. 42, No. 8, 05.2006, p. 1057-1061.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Linking survival of HER2-positive breast carcinoma patients with surgical invasiveness
AU - Tagliabue, Elda
AU - Agresti, Roberto
AU - Casalini, Patrizia
AU - Mariani, Luigi
AU - Carcangiu, Maria Luisa
AU - Balsari, Andrea
AU - Veronesi, Umberto
AU - Ménard, Sylvie
PY - 2006/5
Y1 - 2006/5
N2 - The early peak of relapse in patients with breast carcinomas that overexpress HER2 oncoprotein and dissemination to the axillary lymph nodes might be related to proliferation of micrometastatic lesions induced by EGF family growth factors released at the time of surgery. If the levels of these growth factors have an impact on relapse, the survival of patients with positive nodes and HER2-positive tumours should be dependent on surgery wideness. To test this hypothesis, HER2 status of primary tumours from patients included in a randomized clinical trial addressing conservative quadrantectomy versus radical mastectomy was retrospectively analyzed. In HER2-negative patients, independently of node infiltration, and in HER2-positive patients without node infiltration, no differences in survival according to the type of surgery were observed. In patients with positive nodes and HER2-positive tumours the estimation of the time-dependent log-hazard ratios showed that radical mastectomy significantly increased early death rates (P = 0.037).
AB - The early peak of relapse in patients with breast carcinomas that overexpress HER2 oncoprotein and dissemination to the axillary lymph nodes might be related to proliferation of micrometastatic lesions induced by EGF family growth factors released at the time of surgery. If the levels of these growth factors have an impact on relapse, the survival of patients with positive nodes and HER2-positive tumours should be dependent on surgery wideness. To test this hypothesis, HER2 status of primary tumours from patients included in a randomized clinical trial addressing conservative quadrantectomy versus radical mastectomy was retrospectively analyzed. In HER2-negative patients, independently of node infiltration, and in HER2-positive patients without node infiltration, no differences in survival according to the type of surgery were observed. In patients with positive nodes and HER2-positive tumours the estimation of the time-dependent log-hazard ratios showed that radical mastectomy significantly increased early death rates (P = 0.037).
KW - Breast cancer
KW - HER2
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=33646431425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646431425&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2005.12.021
DO - 10.1016/j.ejca.2005.12.021
M3 - Article
VL - 42
SP - 1057
EP - 1061
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 8
ER -