LINX® Reflux Management System in chronic gastroesophageal reflux: A novel effective technology for restoring the natural barrier to reflux

Luigi Bonavina, Greta Saino, John C. Lipham, Tom R. Demeester

Research output: Contribution to journalArticle

Abstract

Gastroesophageal reflux disease (GERD) results from incompetency of the lower esophageal sphincter that allows the contents of the stomach to reflux into the esophagus, the airways, and the mouth. The disease affects about 10% of the western population and has a profound negative impact on quality of life. The majority of patients are successfully treated with proton-pump inhibitors, but up to 40% have incomplete relief of symptoms even after dose adjustment. The laparoscopic Nissen fundoplication represents the surgical gold standard, but is largely underused because of the level of technical difficulty and the prevalence of side effects. These factors have contributed to the propensity of patients to continue with medical therapy despite inadequate symptom control and complications of the disease. As a consequence, a significant 'therapy gap' in the treatment of GERD remains evident in current clinical practice. The LINX® Reflux Management System (Torax Medical, St. Paul, MN, USA) is designed to provide a permanent solution to GERD by augmenting the sphincter barrier with a standardized, reproducible laparoscopic procedure that does not alter gastric anatomy and is easily reversible. Two single-group trials confirmed that a magnetic device designed to augment the lower esophageal sphincter can be safely and effectively implanted using a standard laparoscopic approach. The device decreased esophageal acid exposure, improved reflux symptoms and quality of life, and allowed cessation of proton-pump inhibitors in the majority of patients.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalTherapeutic Advances in Gastroenterology
Volume6
Issue number4
DOIs
Publication statusPublished - Jul 2013

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Gastroesophageal Reflux
Lower Esophageal Sphincter
Proton Pump Inhibitors
Technology
Quality of Life
Equipment and Supplies
Fundoplication
Gastrointestinal Contents
Esophagus
Mouth
Anatomy
Stomach
Therapeutics
Acids
Population

Keywords

  • adenocarcinoma
  • Barrett's
  • esophagitis
  • fundoplication
  • gastroesophageal reflux disease
  • heartburn
  • lower esophageal sphincter augmentation
  • Nissen
  • proton-pump inhibitors
  • regurgitation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

LINX® Reflux Management System in chronic gastroesophageal reflux : A novel effective technology for restoring the natural barrier to reflux. / Bonavina, Luigi; Saino, Greta; Lipham, John C.; Demeester, Tom R.

In: Therapeutic Advances in Gastroenterology, Vol. 6, No. 4, 07.2013, p. 261-268.

Research output: Contribution to journalArticle

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