Many neoplastic diseases are reported to be accompanied by the presence or increase in definite biological substances identified as tumour markers. This field of research has been developing for 25 years and is of interest for clinical application. Recent investigations placed attention on tumour cell membrane components with special regard to surface glycoproteins and glycolipids. Serum and plasma lipid bound sialic acid or lipid associated acid (LSA) has proved to be a valuable tumour marker in patients suffering from different malignancies. These data followed pioneering studies on sialoglycolipid alterations in brain tumours, gastric and colon carcinomas, malignant melanomas, and leukemic diseases. The determination of serum lipid sialic acid in: 48 laryngeal carcinomas, 20 benign laryngeal tumours and 22 latero-cervical lymph node metachronous metastases show a positive correlation exists only with malignancies. LSA monitoring showed an increase in the neoplastic patients and higher values in the post-operative determination. This was then followed by a readjustment into the normal range within 30 days. Benign tumour excision induced values within the normal range. Any lymph node post-surgical enlargements accompanied by increased LSA constantly indicates metachronous metastases. The significance of these data are stressed in relation to the surgical choice and the neoplastic patient monitoring.
|Translated title of the contribution||Lipid bound sialic acid (LSA): Biological marker in laryngeal carcinoma|
|Number of pages||8|
|Journal||Acta Otorhinolaryngologica Italica|
|Publication status||Published - 1985|
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