Lipid-modified proteins as biomarkers for cardiovascular disease: A review

N. Ferri, R. Paoletti, Alberto Corsini

Research output: Contribution to journalArticle

Abstract

Lipid-modified proteins are classified based on the identity of the attached lipid, a post- or contranslational modification required for their biological function. At least five different lipid modifications of cysteines, glycines and other residues on the COOH- and NH2-terminal domains have been described. Cysteine residues may be modified by the addition of a 16-carbon saturated fatty acyl group by a labile thioester bond (palmitoylation) or by prenylation processes that catalyze the formation of thioether bond with mevalonate derived isoprenoids, farnesol. and geranylgeraniol. The NH2-terminal glycine residues may undergo a quite distinct process involving the formation of an amide bond with a 14-carbon saturated acyl group (myristoylation), while glycine residues in the COOH-terminal may be covalently attached with a cholesterol moiety by an ester bond. Finally, cell surface proteins can be anchored to the membrane through the addition of glycosylphosphatidylinositol moiety. Several lines of evidence suggest that lipid-modified proteins are directly involved in different steps of the development of lesions of atherosclerosis, from leukocyte recruitment to plaque rupture, and their expression or lipid modification are likely altered during atherogenesis. This review will briefly summarize the different enzymatic pathways of lipid modification and propose a series of lipid-modified proteins that can be used as biomarkers for cardiovascular disease.

Original languageEnglish
Pages (from-to)219-237
Number of pages19
JournalBiomarkers
Volume10
Issue number4
DOIs
Publication statusPublished - Jul 2005

Keywords

  • Atherosclerosis
  • Farnesol
  • Geranylgeraniol
  • Mevalonate pathway
  • Prenylated proteins
  • Statin

ASJC Scopus subject areas

  • Biotechnology
  • Toxicology

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