Lipid peroxidation and antioxidant status in adults receiving lipid- based home parenteral nutrition

Loris Pironi, Enrico Ruggeri, Carola Zolezzi, Lucia Savarino, Elena Incasa, Andrea Belluzzi, Alessandra Munarini, Sandro Piazzi, Maurizio Tolomelli, Arturo Pizzoferrato, Mario Miglioli

Research output: Contribution to journalArticle

Abstract

Background: Infusion of lipid emulsions rich in polyunsaturated fatty acids (PUFAs) may increase lipid peroxidation, which is counteracted mainly by superoxide dismutase (SOD) (a zinc-, copper-, and manganese-dependent enzyme), selenium-dependent glutathione peroxidase (Se-GSHPx), and α- tocopherol. Objective: We investigated lipid peroxidation and antioxidant status in patients receiving home parenteral nutrition (HPN) providing variable amounts of a lipid emulsion rich in PUFAs, and α-tocopherol, zinc, copper, and manganese as recommended by the American Medical Association, and no selenium. Design: Serum malondialdehyde, plasma α-tocopherol, selenium, Se-GSHPx, PUFAs, and red blood cell Se-GSHPx and SOD were evaluated in 12 patients and in 25 healthy control subjects. Malondialdehyde was also assessed in a group of 40 healthy control subjects. Results: Patients had significantly higher concentrations of malondialdehyde and SOD and lower α- tocopherol concentrations and selenium nutritional status. Linear regression analysis showed that malondialdehyde was associated with the daily PUFA load (r = 0.69, P <0.03) and with plasma α-tocopherol (r = -0.59, P<0.05), but stepwise multiple regression analysis confirmed only the association between malondialdehyde and α-tocopherol; plasma α-tocopherol was associated with the daily PUFA load (r = -0.65, P <0.04) and with the duration of HPN (r = - 0.74, P<0.02). Conclusions: In HPN patients, the peroxidative stress due to lipid emulsions rich in PUFAs is counteracted primarily by α-tocopherol. The dosages of α-tocopherol, zinc, copper, and manganese recommended by the American Medical Association appear sufficient to sustain SOD activity but inadequate to maintain α-tocopherol nutritional status. HPN formulations should be supplemented with selenium.

Original languageEnglish
Pages (from-to)888-893
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume68
Issue number4
Publication statusPublished - Oct 1998

Keywords

  • α-tocopherol
  • Adults
  • Antioxidants
  • Glutathione peroxidase
  • Home parenteral nutrition
  • Humans
  • Lipid peroxidation
  • Malondialdehyde
  • Polyunsaturated fatty acids
  • Selenium
  • Superoxide dismutase
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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    Pironi, L., Ruggeri, E., Zolezzi, C., Savarino, L., Incasa, E., Belluzzi, A., Munarini, A., Piazzi, S., Tolomelli, M., Pizzoferrato, A., & Miglioli, M. (1998). Lipid peroxidation and antioxidant status in adults receiving lipid- based home parenteral nutrition. American Journal of Clinical Nutrition, 68(4), 888-893.