Lipid peroxidation and the coagulation system in aids patients

R. Trotti, M. Rondanelli, A. Anesi, V. Rizzo, R. Brustia, A. Depaoli

Research output: Contribution to journalArticle

Abstract

Oxidative stress has been shown to induce human immunodeficiency virus (HIV) replication in vitro and DNA damage in infected cells as well. Moreover, lipid peroxidation promoted by oxidative stress and hydroxyl radical formation seems to activate thrombin generation in platelet-poor plasma. Such abnormalities could be responsible for the procoagulant activity observed in HIV infected patients. We evaluated malondialdehyde (MDA), a specific index of free radical-dependent damage marker, erythrocyte glutathione peroxidase (GSH-Px) and PAI-1 activities, prothrombin fragments 1+2 (Fl+2) and Ddimer levels, in 22 HIV patients (10 M, 12 F, aged 35±10), classified CDC C3 (CD4+ below 200×106/L), and in 20 matched healthy controls. The index of peroxidation MDA (7.15±1.28 ntnol/L vs 4.16±0.63 μmol/L; p

Original languageEnglish
Pages (from-to)132
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 3
Publication statusPublished - 1996

Fingerprint

Lipid Peroxidation
HIV
Malondialdehyde
Oxidative Stress
Plasminogen Activator Inhibitor 1
Centers for Disease Control and Prevention (U.S.)
Virus Replication
Glutathione Peroxidase
Thrombin
Hydroxyl Radical
DNA Damage
Free Radicals
Blood Platelets
Erythrocytes
In Vitro Techniques
prothrombin fragment 1
prothrombin fragment 2

ASJC Scopus subject areas

  • Hematology

Cite this

Trotti, R., Rondanelli, M., Anesi, A., Rizzo, V., Brustia, R., & Depaoli, A. (1996). Lipid peroxidation and the coagulation system in aids patients. Fibrinolysis, 10(SUPPL. 3), 132.

Lipid peroxidation and the coagulation system in aids patients. / Trotti, R.; Rondanelli, M.; Anesi, A.; Rizzo, V.; Brustia, R.; Depaoli, A.

In: Fibrinolysis, Vol. 10, No. SUPPL. 3, 1996, p. 132.

Research output: Contribution to journalArticle

Trotti, R, Rondanelli, M, Anesi, A, Rizzo, V, Brustia, R & Depaoli, A 1996, 'Lipid peroxidation and the coagulation system in aids patients', Fibrinolysis, vol. 10, no. SUPPL. 3, pp. 132.
Trotti R, Rondanelli M, Anesi A, Rizzo V, Brustia R, Depaoli A. Lipid peroxidation and the coagulation system in aids patients. Fibrinolysis. 1996;10(SUPPL. 3):132.
Trotti, R. ; Rondanelli, M. ; Anesi, A. ; Rizzo, V. ; Brustia, R. ; Depaoli, A. / Lipid peroxidation and the coagulation system in aids patients. In: Fibrinolysis. 1996 ; Vol. 10, No. SUPPL. 3. pp. 132.
@article{36c273fa2ce549ce90fc1e798ee3cffc,
title = "Lipid peroxidation and the coagulation system in aids patients",
abstract = "Oxidative stress has been shown to induce human immunodeficiency virus (HIV) replication in vitro and DNA damage in infected cells as well. Moreover, lipid peroxidation promoted by oxidative stress and hydroxyl radical formation seems to activate thrombin generation in platelet-poor plasma. Such abnormalities could be responsible for the procoagulant activity observed in HIV infected patients. We evaluated malondialdehyde (MDA), a specific index of free radical-dependent damage marker, erythrocyte glutathione peroxidase (GSH-Px) and PAI-1 activities, prothrombin fragments 1+2 (Fl+2) and Ddimer levels, in 22 HIV patients (10 M, 12 F, aged 35±10), classified CDC C3 (CD4+ below 200×106/L), and in 20 matched healthy controls. The index of peroxidation MDA (7.15±1.28 ntnol/L vs 4.16±0.63 μmol/L; p",
author = "R. Trotti and M. Rondanelli and A. Anesi and V. Rizzo and R. Brustia and A. Depaoli",
year = "1996",
language = "English",
volume = "10",
pages = "132",
journal = "Fibrinolysis and Proteolysis",
issn = "1369-0191",
publisher = "Churchill Livingstone",
number = "SUPPL. 3",

}

TY - JOUR

T1 - Lipid peroxidation and the coagulation system in aids patients

AU - Trotti, R.

AU - Rondanelli, M.

AU - Anesi, A.

AU - Rizzo, V.

AU - Brustia, R.

AU - Depaoli, A.

PY - 1996

Y1 - 1996

N2 - Oxidative stress has been shown to induce human immunodeficiency virus (HIV) replication in vitro and DNA damage in infected cells as well. Moreover, lipid peroxidation promoted by oxidative stress and hydroxyl radical formation seems to activate thrombin generation in platelet-poor plasma. Such abnormalities could be responsible for the procoagulant activity observed in HIV infected patients. We evaluated malondialdehyde (MDA), a specific index of free radical-dependent damage marker, erythrocyte glutathione peroxidase (GSH-Px) and PAI-1 activities, prothrombin fragments 1+2 (Fl+2) and Ddimer levels, in 22 HIV patients (10 M, 12 F, aged 35±10), classified CDC C3 (CD4+ below 200×106/L), and in 20 matched healthy controls. The index of peroxidation MDA (7.15±1.28 ntnol/L vs 4.16±0.63 μmol/L; p

AB - Oxidative stress has been shown to induce human immunodeficiency virus (HIV) replication in vitro and DNA damage in infected cells as well. Moreover, lipid peroxidation promoted by oxidative stress and hydroxyl radical formation seems to activate thrombin generation in platelet-poor plasma. Such abnormalities could be responsible for the procoagulant activity observed in HIV infected patients. We evaluated malondialdehyde (MDA), a specific index of free radical-dependent damage marker, erythrocyte glutathione peroxidase (GSH-Px) and PAI-1 activities, prothrombin fragments 1+2 (Fl+2) and Ddimer levels, in 22 HIV patients (10 M, 12 F, aged 35±10), classified CDC C3 (CD4+ below 200×106/L), and in 20 matched healthy controls. The index of peroxidation MDA (7.15±1.28 ntnol/L vs 4.16±0.63 μmol/L; p

UR - http://www.scopus.com/inward/record.url?scp=33846686282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846686282&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 132

JO - Fibrinolysis and Proteolysis

JF - Fibrinolysis and Proteolysis

SN - 1369-0191

IS - SUPPL. 3

ER -