Lipid peroxidation and the coagulation system in aids patients

Oxidative stress has been shown to induce human immunodeficiency virus (HIV) replication in vitro and DNA damage in infected cells as well. Moreover, lipid peroxidation promoted by oxidative stress and hydroxyl radical formation seems to activate thrombin generation in platelet-poor plasma. Such abnormalities could be responsible for the procoagulant activity observed in HIV infected patients. We evaluated malondialdehyde (MDA), a specific index of free radical-dependent damage marker, erythrocyte glutathione peroxidase (GSH-Px) and PAI-1 activities, prothrombin fragments 1+2 (Fl+2) and Ddimer levels, in 22 HIV patients (10 M, 12 F, aged 35±10), classified CDC C3 (CD4+ below 200×10^{6/L), and in 20 matched healthy controls. The index of peroxidation MDA (7.15±1.28 ntnol/L vs 4.16±0.63 μmol/L; p}