Lipid profile changes in patients undergoing bariatric surgery: A comparative study between sleeve gastrectomy and mini-gastric bypass

Marco Milone, Roberta Lupoli, Paola Maietta, Alessandro Di Minno, Paolo Bianco, Pasquale Ambrosino, Guido Coretti, Francesco Milone, Matteo Nicola Dario Di Minno, Mario Musella

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Abstract

Objective: To prospectively evaluate the effect of different types of bariatric surgery on lipid profile. Methods: Total cholesterol (TC), High-Density-Lipoprotein cholesterol (HDLc), Low-Density-Lipoprotein cholesterol (LDLc) and triglycerides (TG) levels were evaluated before surgery and at 3 different post-operative time-points (3, 6 and 12 months) in consecutive obese subjects undergoing mini-gastric bypass (MGB) or sleeve gastrectomy (SG). Results: At baseline, 74 MGB and 86 SG subjects were comparable for lipid profile and prevalence of hypercholesterolemia/hypertriglyceridemia. During the post-operative follow-up, both MGB and SG subjects showed significant changes in lipid profile. However, at 3 months, MGB patients showed higher changes in TC (β=0.179, p=0.022) and TG (β=0.265, p=0.001) than those undergoing SG. At 6-month post-operative follow-up, these differences were confirmed only for TC. After a 12-month follow-up, MGB and SG were entirely comparable for changes in lipid profile with the exception of HDLc, whose changes were higher in SG group (β=0.130, p=0.039).Overall, the probability to normalize lipid profile during the 12-month follow-up was similar in MGB and in SG patients (OR:1.24, 95%CI:0.41-3.76, p=0.689). Conclusion: Despites some differences at 3-6 post-operative months, during a 12-month follow-up, SG and MGB showed a similar efficacy in the improvement of lipid profile of obese patients.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalInternational Journal of Surgery
Volume14
DOIs
Publication statusPublished - Feb 1 2015

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Keywords

  • Bariatric surgery
  • Lipid profile
  • Obesity

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Milone, M., Lupoli, R., Maietta, P., Di Minno, A., Bianco, P., Ambrosino, P., Coretti, G., Milone, F., Di Minno, M. N. D., & Musella, M. (2015). Lipid profile changes in patients undergoing bariatric surgery: A comparative study between sleeve gastrectomy and mini-gastric bypass. International Journal of Surgery, 14, 28-32. https://doi.org/10.1016/j.ijsu.2014.12.025