Lipid rafts in lymphocyte activation

Paola Pizzo; Antonella Viola

doi:10.1016/j.micinf.2004.02.017

Lipid rafts in lymphocyte activation

Paola Pizzo, Antonella Viola

Istituto Clinico Humanitas

Research output: Contribution to journal › Article

Abstract

The existence of sphingolipid- and cholesterol-rich membrane microdomains called "lipid rafts", as well as their role in lymphocyte biology, has been widely debated during the last few years. Plasma membrane microdomains seem to be primarily involved in initiation and propagation of the signal transduction cascade associated with lymphocyte activation. In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions.

Original language	English
Pages (from-to)	686-692
Number of pages	7
Journal	Microbes and Infection
Volume	6
Issue number	7
DOIs	https://doi.org/10.1016/j.micinf.2004.02.017
Publication status	Published - Jun 2004

Fingerprint

Keywords

antigen-presenting cells
APC
B cell antigen receptor
BCR
detergent-resistant membrane
DRM
fluorescence resonance energy transfer
FRET
glycosylphosphatidylinositol
GPI
Immunoreceptor triggering
ITAMs
Lymphocyte signalling
Membrane domains
Rafts

ASJC Scopus subject areas

Microbiology
Infectious Diseases

Cite this

Pizzo, P., & Viola, A. (2004). Lipid rafts in lymphocyte activation. Microbes and Infection, 6(7), 686-692. https://doi.org/10.1016/j.micinf.2004.02.017

@article{d44268810546458386dfe6d022cf8166,

title = "Lipid rafts in lymphocyte activation",

abstract = "The existence of sphingolipid- and cholesterol-rich membrane microdomains called {"}lipid rafts{"}, as well as their role in lymphocyte biology, has been widely debated during the last few years. Plasma membrane microdomains seem to be primarily involved in initiation and propagation of the signal transduction cascade associated with lymphocyte activation. In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions.",

keywords = "antigen-presenting cells, APC, B cell antigen receptor, BCR, detergent-resistant membrane, DRM, fluorescence resonance energy transfer, FRET, glycosylphosphatidylinositol, GPI, Immunoreceptor triggering, ITAMs, Lymphocyte signalling, Membrane domains, Rafts",

author = "Paola Pizzo and Antonella Viola",

year = "2004",

month = jun

doi = "10.1016/j.micinf.2004.02.017",

language = "English",

volume = "6",

pages = "686--692",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson SAS",

number = "7",

}

TY - JOUR

T1 - Lipid rafts in lymphocyte activation

AU - Pizzo, Paola

AU - Viola, Antonella

PY - 2004/6

Y1 - 2004/6

N2 - The existence of sphingolipid- and cholesterol-rich membrane microdomains called "lipid rafts", as well as their role in lymphocyte biology, has been widely debated during the last few years. Plasma membrane microdomains seem to be primarily involved in initiation and propagation of the signal transduction cascade associated with lymphocyte activation. In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions.

AB - The existence of sphingolipid- and cholesterol-rich membrane microdomains called "lipid rafts", as well as their role in lymphocyte biology, has been widely debated during the last few years. Plasma membrane microdomains seem to be primarily involved in initiation and propagation of the signal transduction cascade associated with lymphocyte activation. In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions.

KW - antigen-presenting cells

KW - APC

KW - B cell antigen receptor

KW - BCR

KW - detergent-resistant membrane

KW - DRM

KW - fluorescence resonance energy transfer

KW - FRET

KW - glycosylphosphatidylinositol

KW - GPI

KW - Immunoreceptor triggering

KW - ITAMs

KW - Lymphocyte signalling

KW - Membrane domains

KW - Rafts

UR - http://www.scopus.com/inward/record.url?scp=2442713628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442713628&partnerID=8YFLogxK

U2 - 10.1016/j.micinf.2004.02.017

DO - 10.1016/j.micinf.2004.02.017

M3 - Article

C2 - 15158776

AN - SCOPUS:2442713628

VL - 6

SP - 686

EP - 692

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 7

ER -

Access to Document

10.1016/j.micinf.2004.02.017