Lipid rafts in lymphocyte activation

Paola Pizzo, Antonella Viola

Research output: Contribution to journalArticle

Abstract

The existence of sphingolipid- and cholesterol-rich membrane microdomains called "lipid rafts", as well as their role in lymphocyte biology, has been widely debated during the last few years. Plasma membrane microdomains seem to be primarily involved in initiation and propagation of the signal transduction cascade associated with lymphocyte activation. In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions.

Original languageEnglish
Pages (from-to)686-692
Number of pages7
JournalMicrobes and Infection
Volume6
Issue number7
DOIs
Publication statusPublished - Jun 2004

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Keywords

  • antigen-presenting cells
  • APC
  • B cell antigen receptor
  • BCR
  • detergent-resistant membrane
  • DRM
  • fluorescence resonance energy transfer
  • FRET
  • glycosylphosphatidylinositol
  • GPI
  • Immunoreceptor triggering
  • ITAMs
  • Lymphocyte signalling
  • Membrane domains
  • Rafts

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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