Lipid rafts in lymphocyte activation and migration (review)

Santos Mañes, Antonella Viola

Research output: Contribution to journalArticlepeer-review

Abstract

Functional polarization of leukocytes is a requisite to accomplish immune function. Immune synapse formation or chemotaxis requires asymmetric redistribution of membrane receptors, signaling molecules and the actin cytoskeleton. There is increasing evidence that compartmentalization of the plasma membrane into distinct lipid microdomains is pivotal in establishing and maintaining leukocyte polarity. Specific rafts assemble into large-scale domains to create plasma membrane asymmetries at specific cell locations, thus coordinating temporally and spatially cell signaling in these processes. In this review we discuss the roles of lipid rafts as organizers of T lymphocyte polarity during cell activation and migration.

Original languageEnglish
Pages (from-to)59-69
Number of pages11
JournalMolecular Membrane Biology
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • Costimulation
  • Immunological synapse
  • Lipid rafts
  • Lymphocyte polarization
  • Migration

ASJC Scopus subject areas

  • Cell Biology

Fingerprint

Dive into the research topics of 'Lipid rafts in lymphocyte activation and migration (review)'. Together they form a unique fingerprint.

Cite this