Lipidomic analysis of fatty acids in erythrocytes of coeliac patients before and after a gluten-free diet intervention: A comparison with healthy subjects

Giuseppe Riezzo, Carla Ferreri, Antonella Orlando, Manuela Martulli, Benedetta D'Attoma, Francesco Russo

Research output: Contribution to journalArticle

Abstract

Coeliac disease (CD) patients may exhibit a pro-inflammatory profile and fatty acids (FA) can influence inflammation through a variety of cellular pathways in them. The aims of the present study were to (1) evaluate the FA composition of erythrocytes obtained from newly diagnosed CD patients by lipidomic analysis and compare it with that in healthy subjects and (2) determine the effects of 1-year gluten-free diet (GFD) intervention. A total of twenty CD patients (five men and fifteen women; mean age 34.0 (sem 1.7) years) were evaluated at diagnosis and after 1 year of GFD intervention. A total of twenty healthy subjects (seven men and thirteen women; mean age 40.2 (sem 2.5) years) served as controls. CD patients on an unrestricted diet exhibited a significant 2.08-fold higher concentration of arachidic acid when compared with healthy subjects, suggesting that it can be considered as a putative marker of CD. Besides, the arachidonic acid (AA):dihomo-γ-linolenic acid ratio was 2.01-fold significantly lower in CD patients than in healthy subjects (P

Original languageEnglish
Pages (from-to)1787-1796
Number of pages10
JournalBritish Journal of Nutrition
Volume112
Issue number11
DOIs
Publication statusPublished - Dec 14 2014

Keywords

  • Coeliac disease
  • Erythrocyte membranes
  • Fatty acids
  • Lipidomic analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

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