Lipids in serum and sebum

The influence of the general lipid metabolism on the sebum synthesis in the sebaceous gland is still an underinvestigated area of the pathogenetic mechanisms of acne development. The evidence that acne is prevalently observed in the western world populations implies a role of dietary habits, energy supply, and food complexity as co-causative factors of the disease [1]. Moreover, lipid metabolism is not a mere processing of the food introduced with the diet, but it is the result of the complex interaction between dietary habits and genetic background. This complex interaction affects the lipid uptake from the gastrointestinal tract, as well as the biosynthesis of lipoproteins in the liver and their sequestration in the peripheral tissues, which likely include skin.