Lipofibromatosis: Magnetic resonance imaging features and pathological correlation in three cases

Daniela Vogel, Alberto Righi, Jennifer Kreshak, Angelo Paolo Dei Tos, Biagio Merlino, Eugenio Brunocilla, Daniel Vanel

Research output: Contribution to journalArticlepeer-review

Abstract

Lipofibromatosis is a rare, benign, but infiltrative, soft tissue tumor seen in children. We present three cases of lipofibromatosis, each with different magnetic resonance imaging features and correlate this with the histological findings. The patients comprised two males and one female who presented in infancy; at birth, 5 months, and 7 months of age. Clinically, the masses were painless and slow-growing. The masses ranged in size from 2 to 6 cm and involved the distal extremities in two cases (one foot, one wrist) and the trunk. Magnetic resonance imaging showed lipomatous lesions with varying amounts of adipose and solid components in each case. There were no capsules at the periphery of the lesions. One case showed a fat-predominant lesion, another an equal mixture of fat and solid tissue, and the third was predominantly solid. This was reflected in the histology, which showed corresponding features. Radiological and histopathological differential diagnoses are reviewed.

Original languageEnglish
Pages (from-to)633-639
Number of pages7
JournalSkeletal Radiology
Volume43
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Lipofibromatosis
  • MRI
  • Pediatric
  • Soft tissue neoplasm

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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