Lipoprotein (a) is related to coronary atherosclerotic burden and a vulnerable plaque phenotype in angiographically obstructive coronary artery disease

Giampaolo Niccoli, Diana Cin, Giancarla Scalone, Mario Panebianco, Sofia Abbolito, Nicola Cosentino, Francesca Jacoangeli, Hesham Refaat, Giovanna Gallo, Gerardo Salerno, Massimo Volpe, Filippo Crea, Luciano De Biase

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. Aim: We aim at assessing CAD burden by coronary angiography and plaque features including thin cap fibroatheroma (TCFA) by optical coherence tomography (OCT) in consecutive patients presenting with acute coronary syndrome (ACS) and obstructive CAD along with serum Lp(a) levels. Methods: This study comprises an angiographic and an OCT cohort. A total of 500 ACS patients (370 men, average age 66 ± 11) were enrolled for the angiographic cohort and 51 ACS patients (29 males, average age 65 ± 11) were enrolled for the OCT cohort. Angiographic CAD severity was assessed by Sullivan score and by Bogaty score including stenosis score and extent index. OCT plaque features were evaluated at the site of the minimal lumen area and along the culprit segment. Results: In the angiographic cohort, at multivariate analysis, Lp(a) was a weak independent predictor of Sullivan score (p <0.0001), stenosis score (p <0.0001) and extent index (p <0.0001). In the OCT cohort, patients with higher Lp(a) levels (≥30 md/dl) compared to patients with lower Lp(a) levels (

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalAtherosclerosis
Volume246
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Lipoprotein(a)
Optical Coherence Tomography
Coronary Artery Disease
Acute Coronary Syndrome
Phenotype
Pathologic Constriction
Atherosclerotic Plaques
Coronary Angiography
Rupture
Multivariate Analysis
Lipids
Serum

Keywords

  • Coronary artery disease
  • Lipoprotein(a)
  • Optical coherence tomography
  • Plaque morphology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lipoprotein (a) is related to coronary atherosclerotic burden and a vulnerable plaque phenotype in angiographically obstructive coronary artery disease. / Niccoli, Giampaolo; Cin, Diana; Scalone, Giancarla; Panebianco, Mario; Abbolito, Sofia; Cosentino, Nicola; Jacoangeli, Francesca; Refaat, Hesham; Gallo, Giovanna; Salerno, Gerardo; Volpe, Massimo; Crea, Filippo; De Biase, Luciano.

In: Atherosclerosis, Vol. 246, 01.03.2016, p. 214-220.

Research output: Contribution to journalArticle

Niccoli, G, Cin, D, Scalone, G, Panebianco, M, Abbolito, S, Cosentino, N, Jacoangeli, F, Refaat, H, Gallo, G, Salerno, G, Volpe, M, Crea, F & De Biase, L 2016, 'Lipoprotein (a) is related to coronary atherosclerotic burden and a vulnerable plaque phenotype in angiographically obstructive coronary artery disease', Atherosclerosis, vol. 246, pp. 214-220. https://doi.org/10.1016/j.atherosclerosis.2016.01.020
Niccoli, Giampaolo ; Cin, Diana ; Scalone, Giancarla ; Panebianco, Mario ; Abbolito, Sofia ; Cosentino, Nicola ; Jacoangeli, Francesca ; Refaat, Hesham ; Gallo, Giovanna ; Salerno, Gerardo ; Volpe, Massimo ; Crea, Filippo ; De Biase, Luciano. / Lipoprotein (a) is related to coronary atherosclerotic burden and a vulnerable plaque phenotype in angiographically obstructive coronary artery disease. In: Atherosclerosis. 2016 ; Vol. 246. pp. 214-220.
@article{aa1b9a129ace4cbea1bf2da077d44062,
title = "Lipoprotein (a) is related to coronary atherosclerotic burden and a vulnerable plaque phenotype in angiographically obstructive coronary artery disease",
abstract = "Background: Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. Aim: We aim at assessing CAD burden by coronary angiography and plaque features including thin cap fibroatheroma (TCFA) by optical coherence tomography (OCT) in consecutive patients presenting with acute coronary syndrome (ACS) and obstructive CAD along with serum Lp(a) levels. Methods: This study comprises an angiographic and an OCT cohort. A total of 500 ACS patients (370 men, average age 66 ± 11) were enrolled for the angiographic cohort and 51 ACS patients (29 males, average age 65 ± 11) were enrolled for the OCT cohort. Angiographic CAD severity was assessed by Sullivan score and by Bogaty score including stenosis score and extent index. OCT plaque features were evaluated at the site of the minimal lumen area and along the culprit segment. Results: In the angiographic cohort, at multivariate analysis, Lp(a) was a weak independent predictor of Sullivan score (p <0.0001), stenosis score (p <0.0001) and extent index (p <0.0001). In the OCT cohort, patients with higher Lp(a) levels (≥30 md/dl) compared to patients with lower Lp(a) levels (",
keywords = "Coronary artery disease, Lipoprotein(a), Optical coherence tomography, Plaque morphology",
author = "Giampaolo Niccoli and Diana Cin and Giancarla Scalone and Mario Panebianco and Sofia Abbolito and Nicola Cosentino and Francesca Jacoangeli and Hesham Refaat and Giovanna Gallo and Gerardo Salerno and Massimo Volpe and Filippo Crea and {De Biase}, Luciano",
year = "2016",
month = "3",
day = "1",
doi = "10.1016/j.atherosclerosis.2016.01.020",
language = "English",
volume = "246",
pages = "214--220",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Lipoprotein (a) is related to coronary atherosclerotic burden and a vulnerable plaque phenotype in angiographically obstructive coronary artery disease

AU - Niccoli, Giampaolo

AU - Cin, Diana

AU - Scalone, Giancarla

AU - Panebianco, Mario

AU - Abbolito, Sofia

AU - Cosentino, Nicola

AU - Jacoangeli, Francesca

AU - Refaat, Hesham

AU - Gallo, Giovanna

AU - Salerno, Gerardo

AU - Volpe, Massimo

AU - Crea, Filippo

AU - De Biase, Luciano

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. Aim: We aim at assessing CAD burden by coronary angiography and plaque features including thin cap fibroatheroma (TCFA) by optical coherence tomography (OCT) in consecutive patients presenting with acute coronary syndrome (ACS) and obstructive CAD along with serum Lp(a) levels. Methods: This study comprises an angiographic and an OCT cohort. A total of 500 ACS patients (370 men, average age 66 ± 11) were enrolled for the angiographic cohort and 51 ACS patients (29 males, average age 65 ± 11) were enrolled for the OCT cohort. Angiographic CAD severity was assessed by Sullivan score and by Bogaty score including stenosis score and extent index. OCT plaque features were evaluated at the site of the minimal lumen area and along the culprit segment. Results: In the angiographic cohort, at multivariate analysis, Lp(a) was a weak independent predictor of Sullivan score (p <0.0001), stenosis score (p <0.0001) and extent index (p <0.0001). In the OCT cohort, patients with higher Lp(a) levels (≥30 md/dl) compared to patients with lower Lp(a) levels (

AB - Background: Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. Aim: We aim at assessing CAD burden by coronary angiography and plaque features including thin cap fibroatheroma (TCFA) by optical coherence tomography (OCT) in consecutive patients presenting with acute coronary syndrome (ACS) and obstructive CAD along with serum Lp(a) levels. Methods: This study comprises an angiographic and an OCT cohort. A total of 500 ACS patients (370 men, average age 66 ± 11) were enrolled for the angiographic cohort and 51 ACS patients (29 males, average age 65 ± 11) were enrolled for the OCT cohort. Angiographic CAD severity was assessed by Sullivan score and by Bogaty score including stenosis score and extent index. OCT plaque features were evaluated at the site of the minimal lumen area and along the culprit segment. Results: In the angiographic cohort, at multivariate analysis, Lp(a) was a weak independent predictor of Sullivan score (p <0.0001), stenosis score (p <0.0001) and extent index (p <0.0001). In the OCT cohort, patients with higher Lp(a) levels (≥30 md/dl) compared to patients with lower Lp(a) levels (

KW - Coronary artery disease

KW - Lipoprotein(a)

KW - Optical coherence tomography

KW - Plaque morphology

UR - http://www.scopus.com/inward/record.url?scp=84955437967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955437967&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2016.01.020

DO - 10.1016/j.atherosclerosis.2016.01.020

M3 - Article

AN - SCOPUS:84955437967

VL - 246

SP - 214

EP - 220

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -