Lipoprotein metabolism and lipoprotein lipase in severe cystic acne

Paolo Pigatto, Gian Franco Altomare, Marco Negri, Aldo Fabrizio Finzi, Glauco Vigotti, Carlo Vergani

Research output: Contribution to journalArticlepeer-review

Abstract

In severe cystic acne we found low levels of high density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A) in the presence of normal total lipids. In a larger number of patients, we always observed significantly lower levels of HDL-C and Apo-A than in either age-matched controls or subjects with acne vulgaris. Since lipoprotein lipase is one major determinant of HDL concentration, we assayed the lipase activity in liver and extrahepatic tissues by the method of Krauss et al. There was highly significant less total and hepatic lipase activity than in age-matched controls. HDL distribution was examined by zonal ultracentrifugation and a decrease in the HDL2 subclass was discovered. Since HDL are inversely correlated to atherosclerosis, cystic acne is one risk factor for atherosclerosis. The linkage between low HDL levels and severe cystic acne should be further investigated.

Original languageEnglish
Pages (from-to)243-246
Number of pages4
JournalDermatology
Volume171
Issue number4
DOIs
Publication statusPublished - 1985

Keywords

  • Cystic acne
  • High density lipoprotein cholesterol
  • Lipoprotein lipase

ASJC Scopus subject areas

  • Dermatology

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