IL METABOLISMO DELLE LIPOPROTEINE NELLA PARETE ARTERIOSA E SUOI RAPPORTI CON LA GENESI DELLA LESIONE ATEROMATOSA

Translated title of the contribution: Lipoprotein metabolism in the arterial wall and its relation to the genesis of atheromatous lesions

G. Gaeta, L. Effuso, N. Maurea, M. Boccalatte, R. Scala, C. Sifola, A. Antignano

Research output: Contribution to journalArticlepeer-review

Abstract

In this review we have concentrated on the ways in which modification of LDL structure may account for foam cell formation. We have presented in vivo evidence as well as in vitro evidence supporting the proposition that modification of native LDL is a prerequisite for foam cell formation and atherogenesis. If further research supports the importance of LDL modification in atherogenesis, a whole new array of possibilities opens itself to us for intervention. At the moment, the only intervention that appears to be feasible is prevention of LDL oxidation; conceivably we might be able to interfere with the aggregation of LDL with itself or with other complexes in the artery wall that appear also to favor initiation of the atherogenic process.

Translated title of the contributionLipoprotein metabolism in the arterial wall and its relation to the genesis of atheromatous lesions
Original languageItalian
Pages (from-to)63-72
Number of pages10
JournalClinica Terapeutica
Volume144
Issue number1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Medicine(all)

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