Lipoprotein remnants and endothelial dysfunction in the postprandial phase

Franco Maria Maggi, Sara Raselli, Liliana Grigore, Laura Redaelli, Simona Fantappiè, Alberico Luigi Catapano

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The objective of this work was to study whether changes in remnant lipoprotein (RLP) plasma levels during the postprandial phase relate to alterations of the endothelial function. Fasted patients (15 moderately dyslipidemic men) were given an oral fat load (OFL), and blood samples were collected before the OFL ingestion (T0) and 2, 4, 6, and 8 h (T2, T4, T6, T8) thereafter. Endothelial function, determined as flow-mediated dilatation (FMD) of the brachial artery, was assessed at the same time points. Triglyceridemia peaked between T4 (5.48 ± 0.64 mmol/liter) and T6 (5.34 ± 0.89 mmol/liter) and decreased at 8 h (4.36 ± 0.87 mmol/liter) after the OFL. FMD decreased significantly 6 h after the OFL consumption (from 16.03 ± 1.32% to 11.53 ± 1.42%, P <0.01). Cholesterol in RLPs increased steadily up to 6 h and decreased at 8 h (T0 0.53 ± 0.10, T6 0.81 ± 0.11, T8 0.73 ± 0.13 mmol/liter). Fasting levels of triglycerides and cholesterol-RLPs (C-RLPs) correlated significantly with FMD at baseline. The decrease in endothelial function at 6 h also significantly correlated with the area under the curve of triglycerides (R = 0.53, P = 0.04). Postprandial C-RLPs (area under the curve), however, showed the best correlation with the decrease of FMD (R = 0.63, P = 0.012). The correlation persisted in a multivariate analysis. We concluded that C-RLPs contribute significantly to the endothelial dysfunction occurring during the postprandial lipemia.

Original languageEnglish
Pages (from-to)2946-2950
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number6
DOIs
Publication statusPublished - Jun 2004

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Lipoproteins
Dilatation
Fats
Cholesterol
Area Under Curve
Triglycerides
Brachial Artery
Hyperlipidemias
Fasting
Blood
Multivariate Analysis
Eating
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Lipoprotein remnants and endothelial dysfunction in the postprandial phase. / Maggi, Franco Maria; Raselli, Sara; Grigore, Liliana; Redaelli, Laura; Fantappiè, Simona; Catapano, Alberico Luigi.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 6, 06.2004, p. 2946-2950.

Research output: Contribution to journalArticle

Maggi, Franco Maria ; Raselli, Sara ; Grigore, Liliana ; Redaelli, Laura ; Fantappiè, Simona ; Catapano, Alberico Luigi. / Lipoprotein remnants and endothelial dysfunction in the postprandial phase. In: Journal of Clinical Endocrinology and Metabolism. 2004 ; Vol. 89, No. 6. pp. 2946-2950.
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