Lipoprotein(a) levels and apolipoprotein(a) polymorphism in type 1 diabetes mellitus: Relationships to microvascular and neurological complications

C. Gazzaruso, A. Garzaniti, P. Buscaglia, G. D'Annunzio, A. Porta, G. Vandelli, R. Lorini, G. Finardi, P. Fratino, D. Geroldi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

To investigate plasma concentrations of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] polymorphism in relation to the presence of microvascular and neurological complications in type 1 diabetes mellitus, 118 young diabetic patients and 127 age-matched controls were recruited. Lp(a) levels were higher in patients than in controls, but the apo(a) isoforms distribution did not differ between the two groups [higher prevalence of isoforms of high relative molecular mass (RMM) in both groups]. Microalbuminuric patients had Lp(a) levels significantly greater than normoalbuminuric patients, and normoalbuminuric patients showed higher Lp(a) levels than controls. Patients with retinopathy or neuropathy showed similar Lp(a) levels to those without retinopathy or neuropathy. No differences in apo(a) isoforms frequencies were observed between subgroups with and without complications (higher prevalence of isoforms of high RMM in every subgroup). However, among patients with retinopathy, those with proliferative retinopathy had higher Lp(a) levels and a different apo(a) isoforms distribution (higher prevalence of isoforms of low RMM) than those with non-proliferative and background retinopathy (higher prevalence of isoforms of high RMM). Our data suggest that young type 1 diabetic patients without microalbuminuria have Lp(a) levels higher than healthy subjects of the same age. Lp(a) levels are further increased in microalbuminuric patients. High Lp(a) levels and apo(a) isoforms of low RMM seem to be associated with the presence of proliferative retinopathy, but have no relation to neuropathy.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalActa Diabetologica
Volume35
Issue number1
DOIs
Publication statusPublished - Apr 1998

Fingerprint

Apoprotein(a)
Lipoprotein(a)
Type 1 Diabetes Mellitus
Protein Isoforms
Healthy Volunteers

Keywords

  • Apolipoprotein(a) polymorphism
  • Insulin-dependent diabetes mellitus
  • Lipoprotein(a)
  • Microangiopathy
  • Neuropathy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Lipoprotein(a) levels and apolipoprotein(a) polymorphism in type 1 diabetes mellitus : Relationships to microvascular and neurological complications. / Gazzaruso, C.; Garzaniti, A.; Buscaglia, P.; D'Annunzio, G.; Porta, A.; Vandelli, G.; Lorini, R.; Finardi, G.; Fratino, P.; Geroldi, D.

In: Acta Diabetologica, Vol. 35, No. 1, 04.1998, p. 13-18.

Research output: Contribution to journalArticle

Gazzaruso, C. ; Garzaniti, A. ; Buscaglia, P. ; D'Annunzio, G. ; Porta, A. ; Vandelli, G. ; Lorini, R. ; Finardi, G. ; Fratino, P. ; Geroldi, D. / Lipoprotein(a) levels and apolipoprotein(a) polymorphism in type 1 diabetes mellitus : Relationships to microvascular and neurological complications. In: Acta Diabetologica. 1998 ; Vol. 35, No. 1. pp. 13-18.
@article{ddc025dca97a4b3e95f6414ac99a2746,
title = "Lipoprotein(a) levels and apolipoprotein(a) polymorphism in type 1 diabetes mellitus: Relationships to microvascular and neurological complications",
abstract = "To investigate plasma concentrations of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] polymorphism in relation to the presence of microvascular and neurological complications in type 1 diabetes mellitus, 118 young diabetic patients and 127 age-matched controls were recruited. Lp(a) levels were higher in patients than in controls, but the apo(a) isoforms distribution did not differ between the two groups [higher prevalence of isoforms of high relative molecular mass (RMM) in both groups]. Microalbuminuric patients had Lp(a) levels significantly greater than normoalbuminuric patients, and normoalbuminuric patients showed higher Lp(a) levels than controls. Patients with retinopathy or neuropathy showed similar Lp(a) levels to those without retinopathy or neuropathy. No differences in apo(a) isoforms frequencies were observed between subgroups with and without complications (higher prevalence of isoforms of high RMM in every subgroup). However, among patients with retinopathy, those with proliferative retinopathy had higher Lp(a) levels and a different apo(a) isoforms distribution (higher prevalence of isoforms of low RMM) than those with non-proliferative and background retinopathy (higher prevalence of isoforms of high RMM). Our data suggest that young type 1 diabetic patients without microalbuminuria have Lp(a) levels higher than healthy subjects of the same age. Lp(a) levels are further increased in microalbuminuric patients. High Lp(a) levels and apo(a) isoforms of low RMM seem to be associated with the presence of proliferative retinopathy, but have no relation to neuropathy.",
keywords = "Apolipoprotein(a) polymorphism, Insulin-dependent diabetes mellitus, Lipoprotein(a), Microangiopathy, Neuropathy",
author = "C. Gazzaruso and A. Garzaniti and P. Buscaglia and G. D'Annunzio and A. Porta and G. Vandelli and R. Lorini and G. Finardi and P. Fratino and D. Geroldi",
year = "1998",
month = "4",
doi = "10.1007/s005920050095",
language = "English",
volume = "35",
pages = "13--18",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer-Verlag Italia s.r.l.",
number = "1",

}

TY - JOUR

T1 - Lipoprotein(a) levels and apolipoprotein(a) polymorphism in type 1 diabetes mellitus

T2 - Relationships to microvascular and neurological complications

AU - Gazzaruso, C.

AU - Garzaniti, A.

AU - Buscaglia, P.

AU - D'Annunzio, G.

AU - Porta, A.

AU - Vandelli, G.

AU - Lorini, R.

AU - Finardi, G.

AU - Fratino, P.

AU - Geroldi, D.

PY - 1998/4

Y1 - 1998/4

N2 - To investigate plasma concentrations of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] polymorphism in relation to the presence of microvascular and neurological complications in type 1 diabetes mellitus, 118 young diabetic patients and 127 age-matched controls were recruited. Lp(a) levels were higher in patients than in controls, but the apo(a) isoforms distribution did not differ between the two groups [higher prevalence of isoforms of high relative molecular mass (RMM) in both groups]. Microalbuminuric patients had Lp(a) levels significantly greater than normoalbuminuric patients, and normoalbuminuric patients showed higher Lp(a) levels than controls. Patients with retinopathy or neuropathy showed similar Lp(a) levels to those without retinopathy or neuropathy. No differences in apo(a) isoforms frequencies were observed between subgroups with and without complications (higher prevalence of isoforms of high RMM in every subgroup). However, among patients with retinopathy, those with proliferative retinopathy had higher Lp(a) levels and a different apo(a) isoforms distribution (higher prevalence of isoforms of low RMM) than those with non-proliferative and background retinopathy (higher prevalence of isoforms of high RMM). Our data suggest that young type 1 diabetic patients without microalbuminuria have Lp(a) levels higher than healthy subjects of the same age. Lp(a) levels are further increased in microalbuminuric patients. High Lp(a) levels and apo(a) isoforms of low RMM seem to be associated with the presence of proliferative retinopathy, but have no relation to neuropathy.

AB - To investigate plasma concentrations of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] polymorphism in relation to the presence of microvascular and neurological complications in type 1 diabetes mellitus, 118 young diabetic patients and 127 age-matched controls were recruited. Lp(a) levels were higher in patients than in controls, but the apo(a) isoforms distribution did not differ between the two groups [higher prevalence of isoforms of high relative molecular mass (RMM) in both groups]. Microalbuminuric patients had Lp(a) levels significantly greater than normoalbuminuric patients, and normoalbuminuric patients showed higher Lp(a) levels than controls. Patients with retinopathy or neuropathy showed similar Lp(a) levels to those without retinopathy or neuropathy. No differences in apo(a) isoforms frequencies were observed between subgroups with and without complications (higher prevalence of isoforms of high RMM in every subgroup). However, among patients with retinopathy, those with proliferative retinopathy had higher Lp(a) levels and a different apo(a) isoforms distribution (higher prevalence of isoforms of low RMM) than those with non-proliferative and background retinopathy (higher prevalence of isoforms of high RMM). Our data suggest that young type 1 diabetic patients without microalbuminuria have Lp(a) levels higher than healthy subjects of the same age. Lp(a) levels are further increased in microalbuminuric patients. High Lp(a) levels and apo(a) isoforms of low RMM seem to be associated with the presence of proliferative retinopathy, but have no relation to neuropathy.

KW - Apolipoprotein(a) polymorphism

KW - Insulin-dependent diabetes mellitus

KW - Lipoprotein(a)

KW - Microangiopathy

KW - Neuropathy

UR - http://www.scopus.com/inward/record.url?scp=7144259084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7144259084&partnerID=8YFLogxK

U2 - 10.1007/s005920050095

DO - 10.1007/s005920050095

M3 - Article

C2 - 9625284

AN - SCOPUS:7144259084

VL - 35

SP - 13

EP - 18

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

IS - 1

ER -