Lipoprotein(a) Levels Are Associated with the Size of Extracranial Arteries in Multiple Sclerosis

Dejan Jakimovski, Robert Zivadinov, Laura Pelizzari, Richard W. Browne, Bianca Weinstock-Guttman, Murali Ramanathan

Research output: Contribution to journalArticle

Abstract

Background: Hyperlipidemia is associated with worse clinical and radiological outcomes in persons with multiple sclerosis (PwMS) and studies show greater MS extracranial arterial vessel pathology. Objective: The aim of this study was to determine the effect of lipid profile measures on extracranial arterial vessels in PwMS and healthy controls (HCs). Methods: Non-contrast magnetic resonance angiography was conducted on 104 PwMS and 41 HCs. The cross-sectional area (CSA) of the common carotid artery (CCA) and vertebral artery (VA) was measured using a semi-automated edge-detection/contouring method at cervical levels C4-C7. The lipid profile was obtained at the time of the scan. Repeated measures analyses adjusted for age, gender, and body mass index were used. Results: In PwMS, age was associated with CCA CSA (F = 7.65, η2 = 0.083, p = 0.007) and lipoprotein(a) [Lp(a)] with VA CSA (F = 13.4, η2 = 0.13, p < 0.001). These associations were not present in HCs. PwMS with Lp(a) ≥30 and ≥50 mg/dL, and within the highest Lp(a) quartile had significantly larger CCA and VA when compared to those with lower Lp(a) threshold values. Total cholesterol and low- and high-density lipoprotein cholesterol were not associated with CCA or VA CSA. Conclusions: Lp(a) levels are associated with CSA of major extracranial arterial vessels in PwMS but not in HCs. The clinical and pathological significance of these associations, if any, remains unknown.

Original languageEnglish
JournalJournal of Vascular Research
DOIs
Publication statusAccepted/In press - Jan 1 2019

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Lipoprotein(a)
Multiple Sclerosis
Vertebral Artery
Arteries
Common Carotid Artery
Lipids
Magnetic Resonance Angiography
Hyperlipidemias
HDL Cholesterol
Body Mass Index
Cholesterol
Pathology

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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Lipoprotein(a) Levels Are Associated with the Size of Extracranial Arteries in Multiple Sclerosis. / Jakimovski, Dejan; Zivadinov, Robert; Pelizzari, Laura; Browne, Richard W.; Weinstock-Guttman, Bianca; Ramanathan, Murali.

In: Journal of Vascular Research, 01.01.2019.

Research output: Contribution to journalArticle

Jakimovski, Dejan ; Zivadinov, Robert ; Pelizzari, Laura ; Browne, Richard W. ; Weinstock-Guttman, Bianca ; Ramanathan, Murali. / Lipoprotein(a) Levels Are Associated with the Size of Extracranial Arteries in Multiple Sclerosis. In: Journal of Vascular Research. 2019.
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abstract = "Background: Hyperlipidemia is associated with worse clinical and radiological outcomes in persons with multiple sclerosis (PwMS) and studies show greater MS extracranial arterial vessel pathology. Objective: The aim of this study was to determine the effect of lipid profile measures on extracranial arterial vessels in PwMS and healthy controls (HCs). Methods: Non-contrast magnetic resonance angiography was conducted on 104 PwMS and 41 HCs. The cross-sectional area (CSA) of the common carotid artery (CCA) and vertebral artery (VA) was measured using a semi-automated edge-detection/contouring method at cervical levels C4-C7. The lipid profile was obtained at the time of the scan. Repeated measures analyses adjusted for age, gender, and body mass index were used. Results: In PwMS, age was associated with CCA CSA (F = 7.65, η2 = 0.083, p = 0.007) and lipoprotein(a) [Lp(a)] with VA CSA (F = 13.4, η2 = 0.13, p < 0.001). These associations were not present in HCs. PwMS with Lp(a) ≥30 and ≥50 mg/dL, and within the highest Lp(a) quartile had significantly larger CCA and VA when compared to those with lower Lp(a) threshold values. Total cholesterol and low- and high-density lipoprotein cholesterol were not associated with CCA or VA CSA. Conclusions: Lp(a) levels are associated with CSA of major extracranial arterial vessels in PwMS but not in HCs. The clinical and pathological significance of these associations, if any, remains unknown.",
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N2 - Background: Hyperlipidemia is associated with worse clinical and radiological outcomes in persons with multiple sclerosis (PwMS) and studies show greater MS extracranial arterial vessel pathology. Objective: The aim of this study was to determine the effect of lipid profile measures on extracranial arterial vessels in PwMS and healthy controls (HCs). Methods: Non-contrast magnetic resonance angiography was conducted on 104 PwMS and 41 HCs. The cross-sectional area (CSA) of the common carotid artery (CCA) and vertebral artery (VA) was measured using a semi-automated edge-detection/contouring method at cervical levels C4-C7. The lipid profile was obtained at the time of the scan. Repeated measures analyses adjusted for age, gender, and body mass index were used. Results: In PwMS, age was associated with CCA CSA (F = 7.65, η2 = 0.083, p = 0.007) and lipoprotein(a) [Lp(a)] with VA CSA (F = 13.4, η2 = 0.13, p < 0.001). These associations were not present in HCs. PwMS with Lp(a) ≥30 and ≥50 mg/dL, and within the highest Lp(a) quartile had significantly larger CCA and VA when compared to those with lower Lp(a) threshold values. Total cholesterol and low- and high-density lipoprotein cholesterol were not associated with CCA or VA CSA. Conclusions: Lp(a) levels are associated with CSA of major extracranial arterial vessels in PwMS but not in HCs. The clinical and pathological significance of these associations, if any, remains unknown.

AB - Background: Hyperlipidemia is associated with worse clinical and radiological outcomes in persons with multiple sclerosis (PwMS) and studies show greater MS extracranial arterial vessel pathology. Objective: The aim of this study was to determine the effect of lipid profile measures on extracranial arterial vessels in PwMS and healthy controls (HCs). Methods: Non-contrast magnetic resonance angiography was conducted on 104 PwMS and 41 HCs. The cross-sectional area (CSA) of the common carotid artery (CCA) and vertebral artery (VA) was measured using a semi-automated edge-detection/contouring method at cervical levels C4-C7. The lipid profile was obtained at the time of the scan. Repeated measures analyses adjusted for age, gender, and body mass index were used. Results: In PwMS, age was associated with CCA CSA (F = 7.65, η2 = 0.083, p = 0.007) and lipoprotein(a) [Lp(a)] with VA CSA (F = 13.4, η2 = 0.13, p < 0.001). These associations were not present in HCs. PwMS with Lp(a) ≥30 and ≥50 mg/dL, and within the highest Lp(a) quartile had significantly larger CCA and VA when compared to those with lower Lp(a) threshold values. Total cholesterol and low- and high-density lipoprotein cholesterol were not associated with CCA or VA CSA. Conclusions: Lp(a) levels are associated with CSA of major extracranial arterial vessels in PwMS but not in HCs. The clinical and pathological significance of these associations, if any, remains unknown.

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