Utilizzo dell'amfotericina B liposomiale nel trattamento della fase acuta e nella profilassi secondaria della leishmaniosi viscerale in un paziente HIV positivo

Translated title of the contribution: Liposomal amphotericin B for treatment of acute phase and secondary prophylaxis of visceral leishmaniasis in a HIV positive patient

G. Murdaca, M. Setti, A. Campelli, M. Ghio, F. Puppo, F. Indiveri

Research output: Contribution to journalArticle

Abstract

The authors describe a clinical case of an HIV+, HBV+ and HCV+ 46-year-old male patient, with a history of drug abuse of intravenous heroin, admitted to their attention for high remittent fever (39 °C), weight loss and severe dysphonia. The increasing severity of dysphonia had required a fiberlaryngoscopic examination which allowed a diagnosis of hypertrophy of vocal chords. The Wright-Giemsa stain performed on vocal chord biopsy evidenced Leishmania infantum. The same protozoon was subsequently also revealed in bone marrow aspirate. The patient underwent a course of therapy with Amphotericin B deoxycolate (0.5 mg/kg) which had to be interrupted due to insurgence of diffuse petechiae and switched to Amphotericin in cholesterinic suspension (2.5 mg/kg every 21 days). After three months, insurgence of high fever related to the infusion induced the start of therapy with liposomal Amphotericin B (3 mg/kg every 28 days) which led in 4 weeks to a complete clinical remission. Prophylaxis with liposomal Amphotericin B is continuing and remission has persisted for 40 months. This case report shows the importance of liposomal Amphotericin B therapy in order either to obtain clinical remission of visceral leishmaniasis or, in secondary prophylaxis, to reduce the risk of the disease's recurrence.

Translated title of the contributionLiposomal amphotericin B for treatment of acute phase and secondary prophylaxis of visceral leishmaniasis in a HIV positive patient
Original languageItalian
Pages (from-to)241-244
Number of pages4
JournalInfezioni in Medicina
Volume8
Issue number4
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Microbiology (medical)

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