Liposome-delivered angiostatin strongly inhibits tumor growth and metastatization in a transgenic model of spontaneous breast cancer

Maria Grazia Sacco, Mario Caniatti, Enrica Mira Catò, Annalisa Frattini, Giulia Chiesa, Roberta Ceruti, Fulvio Adorni, Luigi Zecca, Eugenio Scanziani, Paolo Vezzoni

Research output: Contribution to journalArticle

Abstract

The possibility to inhibit tumor growth by interfering with the formation of new vessels, which most neoplasias depend on, has recently raised considerable interest. An angiogenic switch, in which proliferating cells acquire the ability to direct new vessel formation, is thought to be an early step in the natural history of solid tumors. Using a transgenic model of breast cancer, which shows many similarities to its human counterpart, including ability to metastasize, we targeted angiostatin production to an early stage of tumor formation. Liposome-delivered angiostatin considerably delayed primary tumor growth and, more importantly, inhibited the appearance of lung metastases. These findings can be relevant to the design of therapeutic intervention in humans.

Original languageEnglish
Pages (from-to)2660-2665
Number of pages6
JournalCancer Research
Volume60
Issue number10
Publication statusPublished - May 15 2000

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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