Abstract
Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes or the synthesis of signalling molecules, or inducing structural and metabolic changes in the cell. This activity is the basis for the critical role of lipoxygenases in a number of pathophysiological conditions, both in animals and plants. We review the effects of microgravity on the catalytic efficiency of purified soybean (Glycine max) lipoxygenase-1, as well as the modulation of the activity and expression of 5-lipoxygenase in human erythroleukemia K562 cells subjected to altered gravity. We also outline the molecular properties of the lipoxygenase family and discuss its possible involvement in space-related processes, such as apoptosis (programmed cell death) and immunodepression. Finally, we discuss the modulation of cyclooxygenase activity and expression in K562 cells exposed to altered gravity, because cyclooxygenase catalyzes the oxidation of arachidonate through a pathway different from that catalyzed by lipoxygenase activity.
| Original language | English |
|---|---|
| Title of host publication | Advances in Space Biology and Medicine |
| Pages | 1-17 |
| Number of pages | 17 |
| Volume | 8 |
| Publication status | Published - 2002 |
Publication series
| Name | Advances in Space Biology and Medicine |
|---|---|
| Volume | 8 |
| ISSN (Print) | 15692574 |
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ASJC Scopus subject areas
- Physiology
Cite this
Lipoxygenase activity in altered gravity. / Maccarrone, Mauro; Battista, Natalia; Bari, Monica; Finazzi-Agrò, Alessandro.
Advances in Space Biology and Medicine. Vol. 8 2002. p. 1-17 (Advances in Space Biology and Medicine; Vol. 8).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Lipoxygenase activity in altered gravity
AU - Maccarrone, Mauro
AU - Battista, Natalia
AU - Bari, Monica
AU - Finazzi-Agrò, Alessandro
PY - 2002
Y1 - 2002
N2 - Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes or the synthesis of signalling molecules, or inducing structural and metabolic changes in the cell. This activity is the basis for the critical role of lipoxygenases in a number of pathophysiological conditions, both in animals and plants. We review the effects of microgravity on the catalytic efficiency of purified soybean (Glycine max) lipoxygenase-1, as well as the modulation of the activity and expression of 5-lipoxygenase in human erythroleukemia K562 cells subjected to altered gravity. We also outline the molecular properties of the lipoxygenase family and discuss its possible involvement in space-related processes, such as apoptosis (programmed cell death) and immunodepression. Finally, we discuss the modulation of cyclooxygenase activity and expression in K562 cells exposed to altered gravity, because cyclooxygenase catalyzes the oxidation of arachidonate through a pathway different from that catalyzed by lipoxygenase activity.
AB - Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes or the synthesis of signalling molecules, or inducing structural and metabolic changes in the cell. This activity is the basis for the critical role of lipoxygenases in a number of pathophysiological conditions, both in animals and plants. We review the effects of microgravity on the catalytic efficiency of purified soybean (Glycine max) lipoxygenase-1, as well as the modulation of the activity and expression of 5-lipoxygenase in human erythroleukemia K562 cells subjected to altered gravity. We also outline the molecular properties of the lipoxygenase family and discuss its possible involvement in space-related processes, such as apoptosis (programmed cell death) and immunodepression. Finally, we discuss the modulation of cyclooxygenase activity and expression in K562 cells exposed to altered gravity, because cyclooxygenase catalyzes the oxidation of arachidonate through a pathway different from that catalyzed by lipoxygenase activity.
UR - http://www.scopus.com/inward/record.url?scp=0141721424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141721424&partnerID=8YFLogxK
M3 - Chapter
C2 - 12951691
AN - SCOPUS:0141721424
SN - 0444507353
SN - 9780444507358
VL - 8
T3 - Advances in Space Biology and Medicine
SP - 1
EP - 17
BT - Advances in Space Biology and Medicine
ER -