Abstract
AIM: HPV DNA has never been investigated in nipple discharges (ND) and serum-derived extracellular vesicles, although its presence has been reported in ductal lavage fluids and blood specimens.
MATERIALS & METHODS: We analyzed 50 ND, 22 serum-derived extracellular vesicles as well as 51 pathologic breast tissues for the presence of 16 HPV DNA types.
RESULTS: We show that the presence of HPV DNA in the ND is predictive of HPV DNA-positive breast lesions and that HPV DNA is more represented in intraductal papillomas. We also show the presence of HPV DNA in the serum-derived extracellular vesicles.
CONCLUSION: Our data supports the use of liquid biopsy to detect HPV DNA in breast pathology.
Original language | English |
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Pages (from-to) | 187-194 |
Number of pages | 8 |
Journal | Future Microbiology |
Volume | 13 |
DOIs | |
Publication status | Published - Feb 2018 |
Keywords
- Journal Article