Abstract
AIM: HPV DNA has never been investigated in nipple discharges (ND) and serum-derived extracellular vesicles, although its presence has been reported in ductal lavage fluids and blood specimens.
MATERIALS & METHODS: We analyzed 50 ND, 22 serum-derived extracellular vesicles as well as 51 pathologic breast tissues for the presence of 16 HPV DNA types.
RESULTS: We show that the presence of HPV DNA in the ND is predictive of HPV DNA-positive breast lesions and that HPV DNA is more represented in intraductal papillomas. We also show the presence of HPV DNA in the serum-derived extracellular vesicles.
CONCLUSION: Our data supports the use of liquid biopsy to detect HPV DNA in breast pathology.
| Original language | English |
|---|---|
| Pages (from-to) | 187-194 |
| Number of pages | 8 |
| Journal | Future Microbiology |
| Volume | 13 |
| DOIs | |
| Publication status | Published - Feb 2018 |
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Keywords
- Journal Article
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Liquid biopsy in the diagnosis of HPV DNA in breast lesions. / Carolis, Sabrina De; Pellegrini, Alice; Santini, Donatella; Ceccarelli, Claudio; De Leo, Antonio; Alessandrini, Federica; Arienti, Chiara; Pignatta, Sara; Tesei, Anna; Mantovani, Vilma; Zamagni, Claudio; Taffurelli, Mario; Sansone, Pasquale; Bonafé, Massimiliano; Cricca, Monica.
In: Future Microbiology, Vol. 13, 02.2018, p. 187-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Liquid biopsy in the diagnosis of HPV DNA in breast lesions
AU - Carolis, Sabrina De
AU - Pellegrini, Alice
AU - Santini, Donatella
AU - Ceccarelli, Claudio
AU - De Leo, Antonio
AU - Alessandrini, Federica
AU - Arienti, Chiara
AU - Pignatta, Sara
AU - Tesei, Anna
AU - Mantovani, Vilma
AU - Zamagni, Claudio
AU - Taffurelli, Mario
AU - Sansone, Pasquale
AU - Bonafé, Massimiliano
AU - Cricca, Monica
PY - 2018/2
Y1 - 2018/2
N2 - AIM: HPV DNA has never been investigated in nipple discharges (ND) and serum-derived extracellular vesicles, although its presence has been reported in ductal lavage fluids and blood specimens.MATERIALS & METHODS: We analyzed 50 ND, 22 serum-derived extracellular vesicles as well as 51 pathologic breast tissues for the presence of 16 HPV DNA types.RESULTS: We show that the presence of HPV DNA in the ND is predictive of HPV DNA-positive breast lesions and that HPV DNA is more represented in intraductal papillomas. We also show the presence of HPV DNA in the serum-derived extracellular vesicles.CONCLUSION: Our data supports the use of liquid biopsy to detect HPV DNA in breast pathology.
AB - AIM: HPV DNA has never been investigated in nipple discharges (ND) and serum-derived extracellular vesicles, although its presence has been reported in ductal lavage fluids and blood specimens.MATERIALS & METHODS: We analyzed 50 ND, 22 serum-derived extracellular vesicles as well as 51 pathologic breast tissues for the presence of 16 HPV DNA types.RESULTS: We show that the presence of HPV DNA in the ND is predictive of HPV DNA-positive breast lesions and that HPV DNA is more represented in intraductal papillomas. We also show the presence of HPV DNA in the serum-derived extracellular vesicles.CONCLUSION: Our data supports the use of liquid biopsy to detect HPV DNA in breast pathology.
KW - Journal Article
U2 - 10.2217/fmb-2017-0145
DO - 10.2217/fmb-2017-0145
M3 - Article
C2 - 28975808
VL - 13
SP - 187
EP - 194
JO - Future Microbiology
JF - Future Microbiology
SN - 1746-0913
ER -