Liquid dynamic medicine and N-of-1 clinical trials: A change of perspective in oncology research

Nicola Silvestris, Gennaro Ciliberto, Paolo De Paoli, Giovanni Apolone, Maria Luisa Lavitrano, Marco A. Pierotti, Giorgio Stanta

Research output: Contribution to journalReview article

Abstract

The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the emergence of tumor clonal variants is shaping modern medical oncology., In order to better describe this new therapeutic paradigm we propose the term "Liquid dynamic medicine" in the place of "Personalized or Precision medicine". Clinical validation of the "Liquid dynamic medicine" approach is best captured by N-of-1 trials where each patient acts as tester and control of truly personalized therapies.

Original languageEnglish
Article number128
JournalJournal of Experimental and Clinical Cancer Research
Volume36
Issue number1
DOIs
Publication statusPublished - Sep 13 2017

Keywords

  • Clinical trials
  • Dynamic
  • Fluid
  • N-of-1 trials
  • Personalized medicine
  • Target therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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