LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2

Orly Reiner, Irit Bar-Am, Tamar Sapir, Orit Shmueli, Romeo Carrozzo, Elizabeth A. Lindsay, Antonio Baldini, David H. Ledbetter, Aviv Cahana

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We report here the isolation of a novel cDNA, designatedLIS2,that maps to chromosome 2p11.2 byin situhybridization and demonstrates extremely high sequence similarity to the recently identifiedLIS1gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes forLIS2revealed a pattern of expression resembling that ofLIS1,althoughLIS2is less abundant. Surprisingly,LIS2detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped byin situhybridization to two loci on chromosome 2, 2p11.2 and 2q13-q14. This hybridization was due to the existence ofLIS2pseudogeneLIS2Pon the long arm of chromosome 2.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalGenomics
Volume30
Issue number2
DOIs
Publication statusPublished - Nov 1995

Fingerprint

Classical Lissencephalies and Subcortical Band Heterotopias
Pseudogenes
Chromosomes, Human, Pair 2
Clone Cells
Genes
Skeletal Muscle
Complementary DNA
Chromosomes
Molecular Weight

ASJC Scopus subject areas

  • Genetics

Cite this

Reiner, O., Bar-Am, I., Sapir, T., Shmueli, O., Carrozzo, R., Lindsay, E. A., ... Cahana, A. (1995). LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2. Genomics, 30(2), 251-256. https://doi.org/10.1006/geno.1995.9880

LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2. / Reiner, Orly; Bar-Am, Irit; Sapir, Tamar; Shmueli, Orit; Carrozzo, Romeo; Lindsay, Elizabeth A.; Baldini, Antonio; Ledbetter, David H.; Cahana, Aviv.

In: Genomics, Vol. 30, No. 2, 11.1995, p. 251-256.

Research output: Contribution to journalArticle

Reiner, O, Bar-Am, I, Sapir, T, Shmueli, O, Carrozzo, R, Lindsay, EA, Baldini, A, Ledbetter, DH & Cahana, A 1995, 'LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2', Genomics, vol. 30, no. 2, pp. 251-256. https://doi.org/10.1006/geno.1995.9880
Reiner, Orly ; Bar-Am, Irit ; Sapir, Tamar ; Shmueli, Orit ; Carrozzo, Romeo ; Lindsay, Elizabeth A. ; Baldini, Antonio ; Ledbetter, David H. ; Cahana, Aviv. / LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2. In: Genomics. 1995 ; Vol. 30, No. 2. pp. 251-256.
@article{b2aaf11f7eae423c928319170e4656ce,
title = "LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2",
abstract = "We report here the isolation of a novel cDNA, designatedLIS2,that maps to chromosome 2p11.2 byin situhybridization and demonstrates extremely high sequence similarity to the recently identifiedLIS1gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes forLIS2revealed a pattern of expression resembling that ofLIS1,althoughLIS2is less abundant. Surprisingly,LIS2detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped byin situhybridization to two loci on chromosome 2, 2p11.2 and 2q13-q14. This hybridization was due to the existence ofLIS2pseudogeneLIS2Pon the long arm of chromosome 2.",
author = "Orly Reiner and Irit Bar-Am and Tamar Sapir and Orit Shmueli and Romeo Carrozzo and Lindsay, {Elizabeth A.} and Antonio Baldini and Ledbetter, {David H.} and Aviv Cahana",
year = "1995",
month = "11",
doi = "10.1006/geno.1995.9880",
language = "English",
volume = "30",
pages = "251--256",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2

AU - Reiner, Orly

AU - Bar-Am, Irit

AU - Sapir, Tamar

AU - Shmueli, Orit

AU - Carrozzo, Romeo

AU - Lindsay, Elizabeth A.

AU - Baldini, Antonio

AU - Ledbetter, David H.

AU - Cahana, Aviv

PY - 1995/11

Y1 - 1995/11

N2 - We report here the isolation of a novel cDNA, designatedLIS2,that maps to chromosome 2p11.2 byin situhybridization and demonstrates extremely high sequence similarity to the recently identifiedLIS1gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes forLIS2revealed a pattern of expression resembling that ofLIS1,althoughLIS2is less abundant. Surprisingly,LIS2detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped byin situhybridization to two loci on chromosome 2, 2p11.2 and 2q13-q14. This hybridization was due to the existence ofLIS2pseudogeneLIS2Pon the long arm of chromosome 2.

AB - We report here the isolation of a novel cDNA, designatedLIS2,that maps to chromosome 2p11.2 byin situhybridization and demonstrates extremely high sequence similarity to the recently identifiedLIS1gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes forLIS2revealed a pattern of expression resembling that ofLIS1,althoughLIS2is less abundant. Surprisingly,LIS2detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped byin situhybridization to two loci on chromosome 2, 2p11.2 and 2q13-q14. This hybridization was due to the existence ofLIS2pseudogeneLIS2Pon the long arm of chromosome 2.

UR - http://www.scopus.com/inward/record.url?scp=0028823573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028823573&partnerID=8YFLogxK

U2 - 10.1006/geno.1995.9880

DO - 10.1006/geno.1995.9880

M3 - Article

VL - 30

SP - 251

EP - 256

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -