LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2

Orly Reiner, Irit Bar-Am, Tamar Sapir, Orit Shmueli, Romeo Carrozzo, Elizabeth A. Lindsay, Antonio Baldini, David H. Ledbetter, Aviv Cahana

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

We report here the isolation of a novel cDNA, designatedLIS2,that maps to chromosome 2p11.2 byin situhybridization and demonstrates extremely high sequence similarity to the recently identifiedLIS1gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes forLIS2revealed a pattern of expression resembling that ofLIS1,althoughLIS2is less abundant. Surprisingly,LIS2detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped byin situhybridization to two loci on chromosome 2, 2p11.2 and 2q13-q14. This hybridization was due to the existence ofLIS2pseudogeneLIS2Pon the long arm of chromosome 2.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalGenomics
Volume30
Issue number2
DOIs
Publication statusPublished - Nov 1995

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Classical Lissencephalies and Subcortical Band Heterotopias
Pseudogenes
Chromosomes, Human, Pair 2
Clone Cells
Genes
Skeletal Muscle
Complementary DNA
Chromosomes
Molecular Weight

ASJC Scopus subject areas

  • Genetics

Cite this

Reiner, O., Bar-Am, I., Sapir, T., Shmueli, O., Carrozzo, R., Lindsay, E. A., ... Cahana, A. (1995). LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2. Genomics, 30(2), 251-256. https://doi.org/10.1006/geno.1995.9880

LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2. / Reiner, Orly; Bar-Am, Irit; Sapir, Tamar; Shmueli, Orit; Carrozzo, Romeo; Lindsay, Elizabeth A.; Baldini, Antonio; Ledbetter, David H.; Cahana, Aviv.

In: Genomics, Vol. 30, No. 2, 11.1995, p. 251-256.

Research output: Contribution to journal › Article

Reiner, O, Bar-Am, I, Sapir, T, Shmueli, O, Carrozzo, R, Lindsay, EA, Baldini, A, Ledbetter, DH & Cahana, A 1995, 'LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2', Genomics, vol. 30, no. 2, pp. 251-256. https://doi.org/10.1006/geno.1995.9880
Reiner O, Bar-Am I, Sapir T, Shmueli O, Carrozzo R, Lindsay EA et al. LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2. Genomics. 1995 Nov;30(2):251-256. https://doi.org/10.1006/geno.1995.9880
Reiner, Orly ; Bar-Am, Irit ; Sapir, Tamar ; Shmueli, Orit ; Carrozzo, Romeo ; Lindsay, Elizabeth A. ; Baldini, Antonio ; Ledbetter, David H. ; Cahana, Aviv. / LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2. In: Genomics. 1995 ; Vol. 30, No. 2. pp. 251-256.
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AU - Shmueli, Orit

AU - Carrozzo, Romeo

AU - Lindsay, Elizabeth A.

AU - Baldini, Antonio

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