LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2

Orly Reiner; Irit Bar-Am; Tamar Sapir; Orit Shmueli; Romeo Carrozzo; Elizabeth A. Lindsay; Antonio Baldini; David H. Ledbetter; Aviv Cahana

doi:10.1006/geno.1995.9880

LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2

Orly Reiner, Irit Bar-Am, Tamar Sapir, Orit Shmueli, Romeo Carrozzo, Elizabeth A. Lindsay, Antonio Baldini, David H. Ledbetter, Aviv Cahana

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Abstract

We report here the isolation of a novel cDNA, designatedLIS2,that maps to chromosome 2p11.2 byin situhybridization and demonstrates extremely high sequence similarity to the recently identifiedLIS1gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes forLIS2revealed a pattern of expression resembling that ofLIS1,althoughLIS2is less abundant. Surprisingly,LIS2detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped byin situhybridization to two loci on chromosome 2, 2p11.2 and 2q13-q14. This hybridization was due to the existence ofLIS2pseudogeneLIS2Pon the long arm of chromosome 2.

Original language	English
Pages (from-to)	251-256
Number of pages	6
Journal	Genomics
Volume	30
Issue number	2
DOIs	https://doi.org/10.1006/geno.1995.9880
Publication status	Published - Nov 1995

ASJC Scopus subject areas

Genetics

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10.1006/geno.1995.9880

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Reiner, O., Bar-Am, I., Sapir, T., Shmueli, O., Carrozzo, R., Lindsay, E. A., Baldini, A., Ledbetter, D. H., & Cahana, A. (1995). LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2. Genomics, 30(2), 251-256. https://doi.org/10.1006/geno.1995.9880

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title = "LIS2,Gene and Pseudogene, Homologous toLIS1(Lissencephaly 1), Located on the Short and Long Arms of Chromosome 2",

abstract = "We report here the isolation of a novel cDNA, designatedLIS2,that maps to chromosome 2p11.2 byin situhybridization and demonstrates extremely high sequence similarity to the recently identifiedLIS1gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes forLIS2revealed a pattern of expression resembling that ofLIS1,althoughLIS2is less abundant. Surprisingly,LIS2detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped byin situhybridization to two loci on chromosome 2, 2p11.2 and 2q13-q14. This hybridization was due to the existence ofLIS2pseudogeneLIS2Pon the long arm of chromosome 2.",

author = "Orly Reiner and Irit Bar-Am and Tamar Sapir and Orit Shmueli and Romeo Carrozzo and Lindsay, {Elizabeth A.} and Antonio Baldini and Ledbetter, {David H.} and Aviv Cahana",

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AU - Reiner, Orly

AU - Bar-Am, Irit

AU - Sapir, Tamar

AU - Shmueli, Orit

AU - Carrozzo, Romeo

AU - Lindsay, Elizabeth A.

AU - Baldini, Antonio

AU - Ledbetter, David H.

AU - Cahana, Aviv

PY - 1995/11

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AB - We report here the isolation of a novel cDNA, designatedLIS2,that maps to chromosome 2p11.2 byin situhybridization and demonstrates extremely high sequence similarity to the recently identifiedLIS1gene involved in Miller-Dieker lissencephaly at 17p13.3. Specific probes forLIS2revealed a pattern of expression resembling that ofLIS1,althoughLIS2is less abundant. Surprisingly,LIS2detected an additional, higher molecular weight transcript in adult skeletal muscle. Isolated YAC clones and P1 clones mapped byin situhybridization to two loci on chromosome 2, 2p11.2 and 2q13-q14. This hybridization was due to the existence ofLIS2pseudogeneLIS2Pon the long arm of chromosome 2.

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