Lithium safety in the prophylaxis of bipolar disorders: a study with plasma levels.

M. C. Mauri, V. Laini, M. E. Scalvini, L. S. Volonteri, M. S. Ferrari, G. Panza

Research output: Chapter in Book/Report/Conference proceedingChapter


From many decades efficacy of lithium salts, as mood stabilizers, has been largely recognized, but their tolerability, in particular during intermediate or long-term treatments is still discussed. The most frequently described side effects can affect several organs. Aim of the study was to evaluate lithium carbonate tolerability after a "brief" (1 month-4 years), "intermediate" (5-9 years) and "longterm" (10-21 years) treatment of patients affected by Bipolar Disorders (BD). 27 patients (14 males, 13 females), aged from 20 to 78 years (mean 49.03 years +/- 14.61 SD), affected by BD, type I, according to DSM IV criteria were included into the study. Our data suggest a good tolerability of lithium salts without significant differences among the three different periods of treatment.

Original languageEnglish
Title of host publicationEuropean review for medical and pharmacological sciences
Number of pages7
Publication statusPublished - Mar 1999

ASJC Scopus subject areas

  • Pharmacology


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