Lithium stimulates the binding of GTP to the membranes of PC12 cells cultured with nerve growth factor

Cinzia Volonté

Research output: Contribution to journalArticle

Abstract

The mechanism of action of lithium regarding its therapeutic effects has not yet been established, despite many years of clinical use and scientific investigations. We recently reported that lithium stimulates the phospholipase C of NGF differentiated PC12 cells membranes. In view of the coupling between growth factor receptors, G proteins and phospholipase C, we investigated the effects of lithium on the binding of GTP to the membranes of PC12 cells cultured with NGF. Lithium (1.1 mM) increased 4-5-fold the Bmax of the binding of [3H]GTP to the PC12 membranes. NaF did not induce a similar stimulation.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalNeuroscience Letters
Volume87
Issue number1-2
DOIs
Publication statusPublished - Apr 22 1988

Fingerprint

PC12 Cells
Nerve Growth Factor
Guanosine Triphosphate
Lithium
Membranes
Type C Phospholipases
Growth Factor Receptors
Therapeutic Uses
Protein C
GTP-Binding Proteins
Cell Membrane

Keywords

  • G protein
  • Guanosine triphosphate (GTP) binding
  • Lithium
  • Nerve growth factor (NFG)
  • PC12 cell

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lithium stimulates the binding of GTP to the membranes of PC12 cells cultured with nerve growth factor. / Volonté, Cinzia.

In: Neuroscience Letters, Vol. 87, No. 1-2, 22.04.1988, p. 127-132.

Research output: Contribution to journalArticle

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