Little things that count in transcriptional regulation

Gioacchino Natoli

doi:10.1016/j.cell.2004.08.003

Little things that count in transcriptional regulation

Gioacchino Natoli

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Although the NF-κB transcription factor tolerates significant sequence variations in its DNA binding site, NF-κB sites show remarkable evolutionary stability. In this issue of Cell, Leung et al. (2004) demonstrate that a single nucleotide change in an NF-κB binding site changes the dependence of the promoter on a specific coactivator without affecting NF-κB binding. These data suggest that binding sites may impart a specific configuration to bound transcription factors.

Original language	English
Pages (from-to)	406-408
Number of pages	3
Journal	Cell
Volume	118
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2004.08.003
Publication status	Published - Aug 20 2004

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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10.1016/j.cell.2004.08.003

Cite this

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title = "Little things that count in transcriptional regulation",

abstract = "Although the NF-κB transcription factor tolerates significant sequence variations in its DNA binding site, NF-κB sites show remarkable evolutionary stability. In this issue of Cell, Leung et al. (2004) demonstrate that a single nucleotide change in an NF-κB binding site changes the dependence of the promoter on a specific coactivator without affecting NF-κB binding. These data suggest that binding sites may impart a specific configuration to bound transcription factors.",

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Little things that count in transcriptional regulation

Abstract

ASJC Scopus subject areas

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