Abstract
Although the NF-κB transcription factor tolerates significant sequence variations in its DNA binding site, NF-κB sites show remarkable evolutionary stability. In this issue of Cell, Leung et al. (2004) demonstrate that a single nucleotide change in an NF-κB binding site changes the dependence of the promoter on a specific coactivator without affecting NF-κB binding. These data suggest that binding sites may impart a specific configuration to bound transcription factors.
Original language | English |
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Pages (from-to) | 406-408 |
Number of pages | 3 |
Journal | Cell |
Volume | 118 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 20 2004 |
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology