Little things that count in transcriptional regulation

Research output: Contribution to journalArticlepeer-review


Although the NF-κB transcription factor tolerates significant sequence variations in its DNA binding site, NF-κB sites show remarkable evolutionary stability. In this issue of Cell, Leung et al. (2004) demonstrate that a single nucleotide change in an NF-κB binding site changes the dependence of the promoter on a specific coactivator without affecting NF-κB binding. These data suggest that binding sites may impart a specific configuration to bound transcription factors.

Original languageEnglish
Pages (from-to)406-408
Number of pages3
Issue number4
Publication statusPublished - Aug 20 2004

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology


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