Live attenuated intranasal influenza vaccine

Susanna Esposito, Valentina Montinaro, Elena Groppali, Rossana Tenconi, Margherita Semino, Nicola Principi

Research output: Contribution to journalArticle

Abstract

Annual vaccination is the most effective means of preventing and controlling influenza epidemics, and the traditional trivalent inactivated vaccine (TIV) is by far the most widely used. Unfortunately, it has a number of limitations, the most important of which is its poor immunogenicity in younger children and the elderly, the populations at greatest risk of severe influenza. Live attenuated influenza vaccine (LAIV) has characteristics that can overcome some of these limitations. It does not have to be injected because it is administered intranasally. It is very effective in children and adolescents, among whom it prevents significantly more cases of influenza than the traditional TIV. However, its efficacy in adults has not been adequately documented, which is why it has not been licensed for use by adults by the European health authorities. LAIV is safe and well tolerated by children aged > y and adults, but some concerns arisen regarding its safety in younger children and subjects with previous asthma or with recurrent wheezing. Further studies are needed to solve these problems and to evaluate the possible role of LAIV in the annual vaccination of the general population.

Original languageEnglish
Pages (from-to)115-119
Number of pages5
JournalHuman Vaccines and Immunotherapeutics
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Children
  • Influenza
  • Influenza vaccination
  • Influenza vaccines
  • Pediatrics

ASJC Scopus subject areas

  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Esposito, S., Montinaro, V., Groppali, E., Tenconi, R., Semino, M., & Principi, N. (2012). Live attenuated intranasal influenza vaccine. Human Vaccines and Immunotherapeutics, 8(1), 115-119. https://doi.org/10.4161/hv.8.1.18809