Livedo vasculopathy vs small vessel cutaneous vasculitis: Cytokine and platelet P-selectin studies

Massimo Papi, Biagio Didona, Ornella De Pità, Alessandra Frezzolini, Stefano Di Giulio, Walter De Matteis, Domenico Del Principe, Rino Cavalieri

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the role of platelets and lymphocyte-related immunological mechanisms in livedo vasculopathy (LV) and cutaneous small vessel vasculitis (CSVV). Livedo vasculopathy is thought to be related to the thrombotic occlusion of small and medium-sized dermal vessels. Cutaneous small vessel vasculitis comprises a heterogeneous group of disorders in which the main pathogenetic events could be modulated by circulating cytokines. Design: Case series study of 2 groups of patients affected respectively with LV and CSVV. Setting: A large clinical and research institute for the study and treatment of cutaneous diseases. Patients: Consecutive patients with clinically and histologically proved idiopathic LV (n = 8) and CSVV (n = 20) were studied and compared with healthy donors (n = 20). Patients with potentially correlated systemic diseases were excluded. Main Outcome Measures: Surface expression of platelet P-selectin and circulating level of interleukin (IL) 1β, tumor necrosis factor α (TNF-α), IL-8, IL-2, and soluble IL-2 receptor. Results: The IL-2 and soluble IL-2 receptor levels were significantly higher in serum samples from patients with both LV (1.24 ± 0.46 IU/mL [mean ± SD] vs 0.46 ± 0.24 IU/mL, P

Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalArchives of Dermatology
Volume134
Issue number4
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Dermatology

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