Liver and biliary. Hepatocellular carcinoma in cirrhotic liver in Trieste

M. Melato, M. Valente, E. Mucli, M. M. Muuse, S. Taraglio

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

One hundred consecutive cases of hepatocellular carcinoma (HCC) in cirrhosis observed at autopsy were studied and their pathological aspects were compared with those reported in the literature. The results, which are representative of HCC epidemiology in a geographical area where cirrhosis is mostly due to alcohol abuse, show that similarities in the architectural pattern of HCC and weight of the liver exist between our material and samples with different aetiology and epidemiology. A relationship between the histological grade of HCC and its propensity to metastasize was demonstrated. The reported better prognosis of clear cells per se could not be confirmed, although clear cell HCC occurred exclusively in grade 2. It was also demonstrated that the relationship between grading and staging was strongly influenced by the association of HCC with cirrhosis, which is a fact that is usually overlooked by the common staging (and grading) methods.

Original languageEnglish
Pages (from-to)521-527
Number of pages7
JournalJournal of Gastroenterology and Hepatology
Volume4
Issue number6
Publication statusPublished - 1989

Fingerprint

Hepatocellular Carcinoma
Liver
Fibrosis
Epidemiology
Alcoholism
Autopsy
Weights and Measures

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Liver and biliary. Hepatocellular carcinoma in cirrhotic liver in Trieste. / Melato, M.; Valente, M.; Mucli, E.; Muuse, M. M.; Taraglio, S.

In: Journal of Gastroenterology and Hepatology, Vol. 4, No. 6, 1989, p. 521-527.

Research output: Contribution to journalArticle

Melato, M, Valente, M, Mucli, E, Muuse, MM & Taraglio, S 1989, 'Liver and biliary. Hepatocellular carcinoma in cirrhotic liver in Trieste', Journal of Gastroenterology and Hepatology, vol. 4, no. 6, pp. 521-527.
Melato, M. ; Valente, M. ; Mucli, E. ; Muuse, M. M. ; Taraglio, S. / Liver and biliary. Hepatocellular carcinoma in cirrhotic liver in Trieste. In: Journal of Gastroenterology and Hepatology. 1989 ; Vol. 4, No. 6. pp. 521-527.
@article{ec9e2f4b759d45b88b63bef8d043423d,
title = "Liver and biliary. Hepatocellular carcinoma in cirrhotic liver in Trieste",
abstract = "One hundred consecutive cases of hepatocellular carcinoma (HCC) in cirrhosis observed at autopsy were studied and their pathological aspects were compared with those reported in the literature. The results, which are representative of HCC epidemiology in a geographical area where cirrhosis is mostly due to alcohol abuse, show that similarities in the architectural pattern of HCC and weight of the liver exist between our material and samples with different aetiology and epidemiology. A relationship between the histological grade of HCC and its propensity to metastasize was demonstrated. The reported better prognosis of clear cells per se could not be confirmed, although clear cell HCC occurred exclusively in grade 2. It was also demonstrated that the relationship between grading and staging was strongly influenced by the association of HCC with cirrhosis, which is a fact that is usually overlooked by the common staging (and grading) methods.",
author = "M. Melato and M. Valente and E. Mucli and Muuse, {M. M.} and S. Taraglio",
year = "1989",
language = "English",
volume = "4",
pages = "521--527",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Liver and biliary. Hepatocellular carcinoma in cirrhotic liver in Trieste

AU - Melato, M.

AU - Valente, M.

AU - Mucli, E.

AU - Muuse, M. M.

AU - Taraglio, S.

PY - 1989

Y1 - 1989

N2 - One hundred consecutive cases of hepatocellular carcinoma (HCC) in cirrhosis observed at autopsy were studied and their pathological aspects were compared with those reported in the literature. The results, which are representative of HCC epidemiology in a geographical area where cirrhosis is mostly due to alcohol abuse, show that similarities in the architectural pattern of HCC and weight of the liver exist between our material and samples with different aetiology and epidemiology. A relationship between the histological grade of HCC and its propensity to metastasize was demonstrated. The reported better prognosis of clear cells per se could not be confirmed, although clear cell HCC occurred exclusively in grade 2. It was also demonstrated that the relationship between grading and staging was strongly influenced by the association of HCC with cirrhosis, which is a fact that is usually overlooked by the common staging (and grading) methods.

AB - One hundred consecutive cases of hepatocellular carcinoma (HCC) in cirrhosis observed at autopsy were studied and their pathological aspects were compared with those reported in the literature. The results, which are representative of HCC epidemiology in a geographical area where cirrhosis is mostly due to alcohol abuse, show that similarities in the architectural pattern of HCC and weight of the liver exist between our material and samples with different aetiology and epidemiology. A relationship between the histological grade of HCC and its propensity to metastasize was demonstrated. The reported better prognosis of clear cells per se could not be confirmed, although clear cell HCC occurred exclusively in grade 2. It was also demonstrated that the relationship between grading and staging was strongly influenced by the association of HCC with cirrhosis, which is a fact that is usually overlooked by the common staging (and grading) methods.

UR - http://www.scopus.com/inward/record.url?scp=0024845425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024845425&partnerID=8YFLogxK

M3 - Article

C2 - 2562353

AN - SCOPUS:0024845425

VL - 4

SP - 521

EP - 527

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 6

ER -