L'AUTOTRAPIANTO DI FEGATO. ESPERIENZA CLINICA PRELIMINARE

Translated title of the contribution: Liver autotransplantation. Personal experience

E. Forni, F. Meriggi

Research output: Contribution to journalArticlepeer-review

Abstract

Advances in hepatic transplantation have opened the possibility of bench surgery for liver disease. Thus nonconventional methods such as the ex vivo approach (bench procedure) or the in vivo preserved liver surgery have been performed in selected cases. These methods have been confined to situations and tumour stages otherwise deemed untreatable, or to situations where resection would not have been sufficiently radical. To date, primary liver tumours (hepatocellular, cholangiocellular) and colo-rectal metastases are considered to be suitable conditions. The principles used are those of liver grafting. Hypotermic liver perfusion (UW, 4°C) and venovenous bypass from portal vein and inferior vena cava to the jugular vein using a pump is performed. Our clinical experience with three patients undergoing ex vivo operation of the liver (two patients) or surgery on an ex situ hypotermic perfused liver (one patient) is reported. All the patients (1 M, 2 F) had liver metastases from colonic carcinoma. Major hepatic resections were performed. One patient (M) is alive with intestinal recurrence. Two patients (F) died after 24 and 9 days for sepsis and pulmonary embolism.

Translated title of the contributionLiver autotransplantation. Personal experience
Original languageItalian
Pages (from-to)491-496
Number of pages6
JournalChirurgia
Volume6
Issue number9
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Surgery

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