Liver cell dysplasia and hepatocellular carcinoma: A histological and immunohistochemical study

M. Roncalli, M. Borzio, G. de Biagi, E. Servida, A. Cantaboni, M. Sironi, G. L. Taccagni

Research output: Contribution to journalArticlepeer-review

Abstract

Liver cell dysplasia (LCD) was found in 28 (60%) of 47 patients with hepatocellular carcinoma (HCC); 22 (79%) of them had associatd liver cirrhosis. LCD was more frequently observed in posthepatitic cirrhosis (82%) than in other forms. Carcino-embryonic antigen (CEA), alpha-1-antitrypsin (AAT) and alpha-fetoprotein (AFP), as demonstrated by the peroxidase-antiperoxidase method, were similarly expressed both in normal and in dysplastic cells. Hepatitis B surface antigen was found in eight cases (17%), six of which were associated with LCD. HBsAg was rarely found in dysplastic cells and frequently displayed a peculiar perinuclear pattern. The possible preneoplastic role of LCD is stressed.

Original languageEnglish
Pages (from-to)209-221
Number of pages13
JournalHistopathology
Volume9
Issue number2
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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