Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study

M. Roncalli, M. Borzio, G. de Biagi, A. R. Ferrari, R. Macchi, V. M. Tombesi, E. Servida

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Abstract

Liver cell dysplasia (LCD) was investigated for hepatitis B virus (HBV) markers, alpha-fetoprotein (AFP) and ferritin by serologic and immunohistochemical methods in 101 patients with cirrhosis. LCD was found in 30 cases (29.7%), with the highest incidence in cases of posthepatitic cirrhosis (67%). In the group of dysplastic cirrhosis (DC) 46.6% of the patients had active HBV infection (hepatitis B surface antigen [HBsAg] serum positivity) compared with 7% of the patients with nondysplastic cirrhosis (NDC) (P <0.01). The mean serum AFP concentration was significantly raised in the DC group compared with that in the NDC group (P <0.05). In seven patients with LCD at the initial biopsy, the histologic follow-up showed the persistence of LCD in all cases, and the development of hepatocellular carcinoma (HCC) in three cases. In serologic HBsAg-positive cases, dysplastic cells, at variance with the surrounding liver parenchyma, were almost always negative for tissue HBsAg, and always negative for tissue hepatitis B core antigens (HBcAg). AFP was never detected in either normal or dysplastic cells. Ferritin was found in all cases, but dysplastic foci displayed a lesser amount of this protein. These serologic and immunohistochemical data strongly suggest a preneoplastic significance of LCD. The importance of monitoring cirrhotic patients with LCD and particularly those with HBV infection and/or increased AFP levels with more aggressive follow-up is also stressed.

Original languageEnglish
Pages (from-to)1515-1521
Number of pages7
JournalCancer
Volume57
Issue number8
Publication statusPublished - 1986

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Fibrosis
Liver
alpha-Fetoproteins
Hepatitis B Surface Antigens
Hepatitis B virus
Virus Diseases
Ferritins
Hepatitis B Core Antigens
Physiologic Monitoring
Serum
Hepatocellular Carcinoma
Biopsy
Incidence
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Roncalli, M., Borzio, M., de Biagi, G., Ferrari, A. R., Macchi, R., Tombesi, V. M., & Servida, E. (1986). Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study. Cancer, 57(8), 1515-1521.

Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study. / Roncalli, M.; Borzio, M.; de Biagi, G.; Ferrari, A. R.; Macchi, R.; Tombesi, V. M.; Servida, E.

In: Cancer, Vol. 57, No. 8, 1986, p. 1515-1521.

Research output: Contribution to journalArticle

Roncalli, M, Borzio, M, de Biagi, G, Ferrari, AR, Macchi, R, Tombesi, VM & Servida, E 1986, 'Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study', Cancer, vol. 57, no. 8, pp. 1515-1521.
Roncalli M, Borzio M, de Biagi G, Ferrari AR, Macchi R, Tombesi VM et al. Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study. Cancer. 1986;57(8):1515-1521.
Roncalli, M. ; Borzio, M. ; de Biagi, G. ; Ferrari, A. R. ; Macchi, R. ; Tombesi, V. M. ; Servida, E. / Liver cell dysplasia in cirrhosis. A serologic and immunohistochemical study. In: Cancer. 1986 ; Vol. 57, No. 8. pp. 1515-1521.
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abstract = "Liver cell dysplasia (LCD) was investigated for hepatitis B virus (HBV) markers, alpha-fetoprotein (AFP) and ferritin by serologic and immunohistochemical methods in 101 patients with cirrhosis. LCD was found in 30 cases (29.7{\%}), with the highest incidence in cases of posthepatitic cirrhosis (67{\%}). In the group of dysplastic cirrhosis (DC) 46.6{\%} of the patients had active HBV infection (hepatitis B surface antigen [HBsAg] serum positivity) compared with 7{\%} of the patients with nondysplastic cirrhosis (NDC) (P <0.01). The mean serum AFP concentration was significantly raised in the DC group compared with that in the NDC group (P <0.05). In seven patients with LCD at the initial biopsy, the histologic follow-up showed the persistence of LCD in all cases, and the development of hepatocellular carcinoma (HCC) in three cases. In serologic HBsAg-positive cases, dysplastic cells, at variance with the surrounding liver parenchyma, were almost always negative for tissue HBsAg, and always negative for tissue hepatitis B core antigens (HBcAg). AFP was never detected in either normal or dysplastic cells. Ferritin was found in all cases, but dysplastic foci displayed a lesser amount of this protein. These serologic and immunohistochemical data strongly suggest a preneoplastic significance of LCD. The importance of monitoring cirrhotic patients with LCD and particularly those with HBV infection and/or increased AFP levels with more aggressive follow-up is also stressed.",
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