Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: A prospective study

Mauro Borzio, Savino Bruno, Massimo Roncalli, Guido Colloredo Mels, Giorgio Ramella, Franco Borzio, Gioacchino Leandro, Ernesto Servida, Mauro Podda

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Background/Aims: In humans, the role of liver cell dysplasia as a preneoplastic lesion is still debated. A prospective, long-term, multicenter study was performed to establish whether liver cell dysplasia in cirrhosis is associated with an increased risk for hepatocellular carcinoma (HCC). Methods: A cohort of 307 consecutive patients in whom liver cirrhosis was diagnosed by histology was investigated for development of HCC at 6-month intervals by ultrasonography and determination of α-fetoprotein levels. Results: At enrollment, liver cell dysplasia was found in 75 patients (24%) and in 53% (P <0.01) of those positive for hepatitis B surface antigen (HBsAg). After a mean follow-up of 46 months, HCC was detected in 45 cases, and it was significantly more frequent in patients with liver cell dysplasia (P <0.01) and HBsAg-serum positivity (P <0.01). Multivariate analysis showed that liver cell dysplasia was the most important risk factor correlated with HCC development. HBsAg positivity and age over 60 years were also independent risk factors for HCC. Conclusions: These results indicate that liver cell dysplasia is a major risk factor for HCC, and it should be looked for carefully by pathologists in liver biopsy specimens to identify patients requiring more intensive observation.

Original languageEnglish
Pages (from-to)812-817
Number of pages6
JournalGastroenterology
Volume108
Issue number3
DOIs
Publication statusPublished - 1995

Fingerprint

Hepatocellular Carcinoma
Fibrosis
Prospective Studies
Liver
Hepatitis B Surface Antigens
Fetal Proteins
Liver Cirrhosis
Multicenter Studies
Ultrasonography
Histology
Multivariate Analysis
Observation
Biopsy
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis : A prospective study. / Borzio, Mauro; Bruno, Savino; Roncalli, Massimo; Colloredo Mels, Guido; Ramella, Giorgio; Borzio, Franco; Leandro, Gioacchino; Servida, Ernesto; Podda, Mauro.

In: Gastroenterology, Vol. 108, No. 3, 1995, p. 812-817.

Research output: Contribution to journalArticle

Borzio, Mauro ; Bruno, Savino ; Roncalli, Massimo ; Colloredo Mels, Guido ; Ramella, Giorgio ; Borzio, Franco ; Leandro, Gioacchino ; Servida, Ernesto ; Podda, Mauro. / Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis : A prospective study. In: Gastroenterology. 1995 ; Vol. 108, No. 3. pp. 812-817.
@article{e4108803661b49a1ab1be61438ef29d8,
title = "Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: A prospective study",
abstract = "Background/Aims: In humans, the role of liver cell dysplasia as a preneoplastic lesion is still debated. A prospective, long-term, multicenter study was performed to establish whether liver cell dysplasia in cirrhosis is associated with an increased risk for hepatocellular carcinoma (HCC). Methods: A cohort of 307 consecutive patients in whom liver cirrhosis was diagnosed by histology was investigated for development of HCC at 6-month intervals by ultrasonography and determination of α-fetoprotein levels. Results: At enrollment, liver cell dysplasia was found in 75 patients (24{\%}) and in 53{\%} (P <0.01) of those positive for hepatitis B surface antigen (HBsAg). After a mean follow-up of 46 months, HCC was detected in 45 cases, and it was significantly more frequent in patients with liver cell dysplasia (P <0.01) and HBsAg-serum positivity (P <0.01). Multivariate analysis showed that liver cell dysplasia was the most important risk factor correlated with HCC development. HBsAg positivity and age over 60 years were also independent risk factors for HCC. Conclusions: These results indicate that liver cell dysplasia is a major risk factor for HCC, and it should be looked for carefully by pathologists in liver biopsy specimens to identify patients requiring more intensive observation.",
author = "Mauro Borzio and Savino Bruno and Massimo Roncalli and {Colloredo Mels}, Guido and Giorgio Ramella and Franco Borzio and Gioacchino Leandro and Ernesto Servida and Mauro Podda",
year = "1995",
doi = "10.1016/0016-5085(95)90455-7",
language = "English",
volume = "108",
pages = "812--817",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis

T2 - A prospective study

AU - Borzio, Mauro

AU - Bruno, Savino

AU - Roncalli, Massimo

AU - Colloredo Mels, Guido

AU - Ramella, Giorgio

AU - Borzio, Franco

AU - Leandro, Gioacchino

AU - Servida, Ernesto

AU - Podda, Mauro

PY - 1995

Y1 - 1995

N2 - Background/Aims: In humans, the role of liver cell dysplasia as a preneoplastic lesion is still debated. A prospective, long-term, multicenter study was performed to establish whether liver cell dysplasia in cirrhosis is associated with an increased risk for hepatocellular carcinoma (HCC). Methods: A cohort of 307 consecutive patients in whom liver cirrhosis was diagnosed by histology was investigated for development of HCC at 6-month intervals by ultrasonography and determination of α-fetoprotein levels. Results: At enrollment, liver cell dysplasia was found in 75 patients (24%) and in 53% (P <0.01) of those positive for hepatitis B surface antigen (HBsAg). After a mean follow-up of 46 months, HCC was detected in 45 cases, and it was significantly more frequent in patients with liver cell dysplasia (P <0.01) and HBsAg-serum positivity (P <0.01). Multivariate analysis showed that liver cell dysplasia was the most important risk factor correlated with HCC development. HBsAg positivity and age over 60 years were also independent risk factors for HCC. Conclusions: These results indicate that liver cell dysplasia is a major risk factor for HCC, and it should be looked for carefully by pathologists in liver biopsy specimens to identify patients requiring more intensive observation.

AB - Background/Aims: In humans, the role of liver cell dysplasia as a preneoplastic lesion is still debated. A prospective, long-term, multicenter study was performed to establish whether liver cell dysplasia in cirrhosis is associated with an increased risk for hepatocellular carcinoma (HCC). Methods: A cohort of 307 consecutive patients in whom liver cirrhosis was diagnosed by histology was investigated for development of HCC at 6-month intervals by ultrasonography and determination of α-fetoprotein levels. Results: At enrollment, liver cell dysplasia was found in 75 patients (24%) and in 53% (P <0.01) of those positive for hepatitis B surface antigen (HBsAg). After a mean follow-up of 46 months, HCC was detected in 45 cases, and it was significantly more frequent in patients with liver cell dysplasia (P <0.01) and HBsAg-serum positivity (P <0.01). Multivariate analysis showed that liver cell dysplasia was the most important risk factor correlated with HCC development. HBsAg positivity and age over 60 years were also independent risk factors for HCC. Conclusions: These results indicate that liver cell dysplasia is a major risk factor for HCC, and it should be looked for carefully by pathologists in liver biopsy specimens to identify patients requiring more intensive observation.

UR - http://www.scopus.com/inward/record.url?scp=0028958050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028958050&partnerID=8YFLogxK

U2 - 10.1016/0016-5085(95)90455-7

DO - 10.1016/0016-5085(95)90455-7

M3 - Article

C2 - 7875483

AN - SCOPUS:0028958050

VL - 108

SP - 812

EP - 817

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -