Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: A prospective study

Mauro Borzio, Savino Bruno, Massimo Roncalli, Guido Colloredo Mels, Giorgio Ramella, Franco Borzio, Gioacchino Leandro, Ernesto Servida, Mauro Podda

Research output: Contribution to journalArticle

Abstract

Background/Aims: In humans, the role of liver cell dysplasia as a preneoplastic lesion is still debated. A prospective, long-term, multicenter study was performed to establish whether liver cell dysplasia in cirrhosis is associated with an increased risk for hepatocellular carcinoma (HCC). Methods: A cohort of 307 consecutive patients in whom liver cirrhosis was diagnosed by histology was investigated for development of HCC at 6-month intervals by ultrasonography and determination of α-fetoprotein levels. Results: At enrollment, liver cell dysplasia was found in 75 patients (24%) and in 53% (P <0.01) of those positive for hepatitis B surface antigen (HBsAg). After a mean follow-up of 46 months, HCC was detected in 45 cases, and it was significantly more frequent in patients with liver cell dysplasia (P <0.01) and HBsAg-serum positivity (P <0.01). Multivariate analysis showed that liver cell dysplasia was the most important risk factor correlated with HCC development. HBsAg positivity and age over 60 years were also independent risk factors for HCC. Conclusions: These results indicate that liver cell dysplasia is a major risk factor for HCC, and it should be looked for carefully by pathologists in liver biopsy specimens to identify patients requiring more intensive observation.

Original languageEnglish
Pages (from-to)812-817
Number of pages6
JournalGastroenterology
Volume108
Issue number3
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Gastroenterology

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